微生物组在免疫检查点抑制剂结肠炎和肝炎中的作用

IF 3.2 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Best Practice & Research Clinical Gastroenterology Pub Date : 2024-08-21 DOI:10.1016/j.bpg.2024.101945

Thomas Ryan, Sophia Ling, Andrew Trinh, Jonathan P. Segal

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引用次数: 0

摘要

免疫检查点抑制剂彻底改变了对各种不同类型恶性肿瘤的治疗。然而，胃肠道不良反应，尤其是结肠炎和肝炎相对常见，多达 30% 的患者受到影响。肠道微生物组已成为影响免疫检查点抑制剂疗效及其副作用的潜在因素。本综述将尝试研究微生物组对免疫检查点抑制剂不良反应的影响，以及操纵微生物组作为治疗免疫介导的结肠炎的一种形式的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The role of the microbiome in immune checkpoint inhibitor colitis and hepatitis

Immune checkpoint inhibitors have revolutionised management for a variety of different types of malignancies. However, gastrointestinal adverse effects, in particular colitis and hepatitis, are relatively common with up to 30 % of patients being affected. The gut microbiome has emerged as a potential contributor to both the effectiveness of immune checkpoint inhibitors and their side effects. This review will attempt to examine the impact the microbiome has on adverse effects as a result of immune checkpoint inhibitors as well as the potential for manipulation of the microbiome as a form of management for immune mediated colitis.

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来源期刊

Best Practice & Research Clinical Gastroenterology 医学-胃肠肝病学

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

69 days

期刊介绍： Each topic-based issue of Best Practice & Research Clinical Gastroenterology will provide a comprehensive review of current clinical practice and thinking within the specialty of gastroenterology.