利用自然资源推进登革热病毒治疗

IF 2.9 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2024-08-28 DOI:10.2174/0115680266312717240821062535

Nur Aina Najiha Amin Hapis, Nurshamimi Nor Rashid, Yeun-Mun Choo

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引用次数: 0

摘要

:登革热由登革病毒（DENV）引起，由埃及伊蚊传播，已在 100 多个国家流行。尽管开展了大量研究，但临床上仍缺乏针对登革热的特效药物。因此，进一步探索抗登革热化合物至关重要。近年来，天然产品因其抗病毒特性而备受关注。以植物为基础的药物因其安全性和低毒性而特别具有吸引力。本综述总结了对 DENV 具有潜在抗病毒活性的天然化合物，并强调了它们的作用机制。从传统草药到新型植物分离物，各种化合物针对包膜蛋白、蛋白酶和 RNA 聚合酶等关键病毒蛋白，显示出了抗登革热的前景。探索登革热抗病毒药物的天然来源至关重要。这些化合物为有效治疗和减轻登革热的全球影响带来了希望。

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Harnessing Natural Resources for Advancements in Dengue Virus Treatment

: Dengue fever, caused by the Dengue virus (DENV) and transmitted by Aedes aegypti mosquitoes, has become endemic in over 100 countries. Despite considerable research, there is a lack of specific drugs for clinical use against dengue. Hence, further exploration to identify anti-- dengue compounds is essential. In recent years, natural products have gained attention for their antiviral properties. Plant-based medicines are particularly appealing due to their safety and low toxicity. This review summarizes natural compounds with potential antiviral activity against DENV, highlighting their mechanisms of action. Various compounds, from traditional herbal remedies to novel plant isolates, show promise against dengue, targeting crucial viral proteins like the envelope protein, proteases, and RNA polymerase. Exploring natural sources of antiviral agents against dengue is crucial. These compounds offer hope for effective treatments and mitigating dengue's global impact.

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.