{"title":"SNP 基因对中国人群甲状腺疾病的影响","authors":"Iris Fan, Fenglan Zhou","doi":"10.1101/2024.08.29.24312609","DOIUrl":null,"url":null,"abstract":"Thyroid disorders, particularly hypothyroidism, are prevalent in the Chinese population and have been linked to specific genetic variations. This study investigates the associations between single nucleotide polymorphisms (SNPs) and thyroid disorders in a cohort of Chinese individuals. It aims to explore a novel aspect of thyroid disorders, precisely the effect of different SNPs on the prevalence of developing these disorders, autoimmune diseases, or cancer. It focuses on four SNPs: rs965513, rs179247, rs3087243, and rs231779. The analysis revealed significant associations between these SNPs and thyroid disorders, with the ‘A’ allele of rs179247 showing a higher risk.","PeriodicalId":501419,"journal":{"name":"medRxiv - Endocrinology","volume":"11 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"SNP Genes Effect on Thyroid Disorders in a Chinese Demographic\",\"authors\":\"Iris Fan, Fenglan Zhou\",\"doi\":\"10.1101/2024.08.29.24312609\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Thyroid disorders, particularly hypothyroidism, are prevalent in the Chinese population and have been linked to specific genetic variations. This study investigates the associations between single nucleotide polymorphisms (SNPs) and thyroid disorders in a cohort of Chinese individuals. It aims to explore a novel aspect of thyroid disorders, precisely the effect of different SNPs on the prevalence of developing these disorders, autoimmune diseases, or cancer. It focuses on four SNPs: rs965513, rs179247, rs3087243, and rs231779. The analysis revealed significant associations between these SNPs and thyroid disorders, with the ‘A’ allele of rs179247 showing a higher risk.\",\"PeriodicalId\":501419,\"journal\":{\"name\":\"medRxiv - Endocrinology\",\"volume\":\"11 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"medRxiv - Endocrinology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.08.29.24312609\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Endocrinology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.08.29.24312609","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
甲状腺疾病，尤其是甲状腺功能减退症，在中国人群中很普遍，并且与特定的遗传变异有关。本研究调查了中国人群中单核苷酸多态性（SNPs）与甲状腺疾病之间的关系。研究旨在探索甲状腺疾病的一个新方面，即不同 SNPs 对甲状腺疾病、自身免疫性疾病或癌症发病率的影响。研究重点关注四个 SNPs：rs965513、rs179247、rs3087243 和 rs231779。分析表明，这些 SNP 与甲状腺疾病有明显的关联，其中 rs179247 的 "A "等位基因显示出更高的风险。
SNP Genes Effect on Thyroid Disorders in a Chinese Demographic
Thyroid disorders, particularly hypothyroidism, are prevalent in the Chinese population and have been linked to specific genetic variations. This study investigates the associations between single nucleotide polymorphisms (SNPs) and thyroid disorders in a cohort of Chinese individuals. It aims to explore a novel aspect of thyroid disorders, precisely the effect of different SNPs on the prevalence of developing these disorders, autoimmune diseases, or cancer. It focuses on four SNPs: rs965513, rs179247, rs3087243, and rs231779. The analysis revealed significant associations between these SNPs and thyroid disorders, with the ‘A’ allele of rs179247 showing a higher risk.
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