驾驭不确定性：在重症监护病房管理流感相关侵袭性肺曲霉菌病

IF 4.2 2区生物学 Q2 MICROBIOLOGY

Journal of Fungi Pub Date : 2024-09-07 DOI:10.3390/jof10090639

Giacomo Casalini, Andrea Giacomelli, Laura Galimberti, Riccardo Colombo, Laura Milazzo, Dario Cattaneo, Antonio Castelli, Spinello Antinori

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引用次数: 0

摘要

我们介绍了一例因流感相关肺曲霉菌病（IAPA）入住重症监护病房的棘手病例。患者的临床病程主要表现为难治性真菌肺炎和气管支气管炎、三唑类抗真菌药物引起的疑似药物性肝损伤以及耐多药微生物引起的继发性细菌感染，尽管通过治疗药物监测对抗真菌治疗进行了优化，但患者仍最终死亡。该病例凸显了临床医生在管理患有侵袭性真菌感染的重症患者时所面临的复杂性。

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Navigating Uncertainty: Managing Influenza-Associated Invasive Pulmonary Aspergillosis in an Intensive Care Unit

We present a challenging case of a patient admitted to an intensive care unit with influenza-associated pulmonary aspergillosis (IAPA). The clinical course was characterised by refractory fungal pneumonia and tracheobronchitis, suspected drug-induced liver injury due to triazole antifungals, and secondary bacterial infections with multidrug-resistant microorganisms, resulting in a fatal outcome despite the optimisation of antifungal treatment through therapeutic drug monitoring. This case underscores the complexity that clinicians face in managing critically ill patients with invasive fungal infections.

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来源期刊

Journal of Fungi Medicine-Microbiology (medical)

CiteScore

6.70

自引率

14.90%

发文量

1151

审稿时长

11 weeks

期刊介绍： Journal of Fungi (ISSN 2309-608X) is an international, peer-reviewed scientific open access journal that provides an advanced forum for studies related to pathogenic fungi, fungal biology, and all other aspects of fungal research. The journal publishes reviews, regular research papers, and communications in quarterly issues. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on paper length. Full experimental details must be provided so that the results can be reproduced.