黄曲霉中的蓝光传感器 LreA 对萌发和黄曲霉毒素 B1 合成的调控

IF 4.2 2区生物学 Q2 MICROBIOLOGY

Journal of Fungi Pub Date : 2024-09-13 DOI:10.3390/jof10090650

Kunzhi Jia, Yipu Jia, Qianhua Zeng, Zhaoqi Yan, Shihua Wang

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引用次数: 0

摘要

分生孢子对黄曲霉菌的传播非常重要，黄曲霉菌通常会产生黄曲霉毒素 B1（AFB1），对农业食品安全构成威胁。分生孢子的发育通常易受营养状况和光照等环境条件变化的影响。然而，光信号如何参与黄曲霉的分生仍是未知数。本研究发现，LreA 能对蓝光做出反应，并介导黄曲霉分生孢子的发生，这与黄曲霉的中心发育途径有关。同时，蓝光抑制了 AFB1 的生物合成，这也是由 LreA 介导的，并归因于 aflR 和 aflS 表达的转录调控。我们的研究结果揭示了蓝光传感器LreA调控分生和AFB1生物合成的功能和机制，有利于黄曲霉和霉菌毒素的防控。

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Regulation of Conidiation and Aflatoxin B1 Biosynthesis by a Blue Light Sensor LreA in Aspergillus flavus

Conidia are important for the dispersal of Aspergillus flavus, which usually generates aflatoxin B1 (AFB1) and poses a threat to the safety of agricultural food. The development of conidia is usually susceptible to changes in environmental conditions, such as nutritional status and light. However, how the light signal is involved in the conidiation in A. flavus is still unknown. In this study, LreA was identified to respond to blue light and mediate the promotion of conidiation in A. flavus, which is related to the central development pathway. At the same time, blue light inhibited the biosynthesis of AFB1, which was mediated by LreA and attributed to the transcriptional regulation of aflR and aflS expression. Our findings disclosed the function and mechanism of the blue light sensor LreA in regulating conidiation and AFB1 biosynthesis, which is beneficial for the prevention and control of A. flavus and mycotoxins.

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来源期刊

Journal of Fungi Medicine-Microbiology (medical)

CiteScore

6.70

自引率

14.90%

发文量

1151

审稿时长

11 weeks

期刊介绍： Journal of Fungi (ISSN 2309-608X) is an international, peer-reviewed scientific open access journal that provides an advanced forum for studies related to pathogenic fungi, fungal biology, and all other aspects of fungal research. The journal publishes reviews, regular research papers, and communications in quarterly issues. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on paper length. Full experimental details must be provided so that the results can be reproduced.