正链 RNA 病毒复制细胞器一览。

IF 3.3 3区 生物学 Q3 CELL BIOLOGY
Viktoriya G Stancheva,Sumana Sanyal
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引用次数: 0

摘要

膜结合复制细胞器(RO)是各种正链 RNA 病毒的一个统一特征。这些由各种宿主细胞器改变形成的区室为病毒基因组复制提供了一个保护性生态位。一些 RO 的特征是由病毒蛋白形成的跨膜孔。RO 膜将内部与细胞质中的免疫传感器隔开。成像技术的最新进展揭示了各病毒家族 RO 形态和起源的惊人差异。尽管如此,RO 仍具有共同的核心特征,如与宿主蛋白质相互作用,以实现其生物生成以及脂质和能量的转移。为 RO 的生物生成和维持而重组宿主膜需要病毒和宿主因子的协调作用,包括膜弯曲蛋白、脂质修饰酶和用于组织间接触的系链。在这篇《细胞科学一瞥》(Cell Science at a Glance)文章和随附的海报中,我们强调RO是正链RNA病毒的一个普遍特征,依赖于病毒与宿主之间的相互作用,我们在广泛研究的背景下讨论了RO,研究重点是RO作为抗病毒疗法潜在靶点的潜力,以及RO作为理解细胞生物学基本原理模型的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Positive-strand RNA virus replication organelles at a glance.
Membrane-bound replication organelles (ROs) are a unifying feature among diverse positive-strand RNA viruses. These compartments, formed as alterations of various host organelles, provide a protective niche for viral genome replication. Some ROs are characterised by a membrane-spanning pore formed by viral proteins. The RO membrane separates the interior from immune sensors in the cytoplasm. Recent advances in imaging techniques have revealed striking diversity in RO morphology and origin across virus families. Nevertheless, ROs share core features such as interactions with host proteins for their biogenesis and for lipid and energy transfer. The restructuring of host membranes for RO biogenesis and maintenance requires coordinated action of viral and host factors, including membrane-bending proteins, lipid-modifying enzymes and tethers for interorganellar contacts. In this Cell Science at a Glance article and the accompanying poster, we highlight ROs as a universal feature of positive-strand RNA viruses reliant on virus-host interplay, and we discuss ROs in the context of extensive research focusing on their potential as promising targets for antiviral therapies and their role as models for understanding fundamental principles of cell biology.
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来源期刊
Journal of cell science
Journal of cell science 生物-细胞生物学
CiteScore
7.30
自引率
2.50%
发文量
393
审稿时长
1.4 months
期刊介绍: Journal of Cell Science publishes cutting-edge science, encompassing all aspects of cell biology.
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