Fly Fam161是一种重要的中心粒和纤毛过渡区蛋白,具有独特而多样的细胞类型特异性定位。

IF 4.5 3区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Open Biology Pub Date : 2024-09-11 DOI:10.1098/rsob.240036
Ankit Jaiswal,Andrew Boring,Avik Mukherjee,Tomer Avidor-Reiss
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引用次数: 0

摘要

序列相似性家族 161(Fam161)是一个古老的微管结合蛋白家族,位于中心粒和纤毛过渡区(TZ)腔内,在小鼠中进化迅速。然而,它们的适应性作用尚不清楚。在这里,我们利用苍蝇来深入了解它们对细胞类型的特异性适应。Fam161是在苍蝇中发现的FAM161A和FAM161B的唯一同源物。突变Fam161会导致雄性繁殖能力下降和异常的趋地行为。Fam161以细胞类型特异性的方式定位到感觉神经元的中心粒及其特化的TZ(连接纤毛)上,有时只标记中心粒,有时标记中心粒和纤毛TZ,有时标记比其他TZ蛋白更长的不同长度的TZ,从而定义了一个新的纤毛区,即外远端TZ。这些发现表明,Fam161 是一种重要的中心粒和 TZ 蛋白,在果蝇中具有独特的细胞类型特异性定位,可产生细胞类型特异性适应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fly Fam161 is an essential centriole and cilium transition zone protein with unique and diverse cell type-specific localizations.
Family with sequence similarity 161 (Fam161) is an ancient family of microtubule-binding proteins located at the centriole and cilium transition zone (TZ) lumen that exhibit rapid evolution in mice. However, their adaptive role is unclear. Here, we used flies to gain insight into their cell type-specific adaptations. Fam161 is the sole orthologue of FAM161A and FAM161B found in flies. Mutating Fam161 results in reduced male reproduction and abnormal geotaxis behaviour. Fam161 localizes to sensory neuron centrioles and their specialized TZ (the connecting cilium) in a cell type-specific manner, sometimes labelling only the centrioles, sometimes labelling the centrioles and cilium TZ and sometimes labelling the TZ with varying lengths that are longer than other TZ proteins, defining a new ciliary compartment, the extra distal TZ. These findings suggest that Fam161 is an essential centriole and TZ protein with a unique cell type-specific localization in fruit flies that can produce cell type-specific adaptations.
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来源期刊
Open Biology
Open Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
10.00
自引率
1.70%
发文量
136
审稿时长
6-12 weeks
期刊介绍: Open Biology is an online journal that welcomes original, high impact research in cell and developmental biology, molecular and structural biology, biochemistry, neuroscience, immunology, microbiology and genetics.
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