Jiandong Lu, Hang Tian, Shijiao Lu, Yin Hao, Zhicai Lin, Jun Liu, Zhihua Hong
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引用次数: 0
摘要
本研究旨在建立一个预测睾丸生殖细胞肿瘤（TGCT）患者生存结果的提名图模型。TGCT患者的数据来自监测、流行病学和最终结果（SEER）数据库。采用单变量和多变量考克斯分析来确定独立的预测因素。构建了预测总生存期（OS）的提名图，并通过一致性指数（C-index）、校准曲线和决策曲线分析（DCA）进行验证。分析对象包括 12008 名 TGCT 患者。提名图的 C 指数高达 0.844，校准图也充分拟合。决策曲线分析表明，提名图的临床实用性优于肿瘤-结节-转移（TNM）分期。这项研究建立并验证了预测TGCT患者OS的提名图，与TNM分期相比，提名图具有更高的临床价值。我们的提名图将有助于临床医生对TGCT患者进行适当的治疗。
Development and Validation of a Nomogram for Predicting Survival in Patients with Testicular Germ Cell Tumors
The objective of this study was to establish a nomogram model for predicting survival outcomes in patients with testicular germ cell tumors (TGCTs). Data of patients with TGCTs were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database. Univariate and multivariate Cox analyses were used to identify the independent predictors. A nomogram was constructed to predict overall survival (OS), and verified by concordance index (C-index), calibration curve, and decision curve analysis (DCA). The analyzed population comprised 12,008 patients with TGCTs. The nomogram showed a high C-index of 0.844, and the calibration plots were adequately fitted. Decision curve analysis indicated the clinical usefulness of the nomogram, which outperformed the tumor-node-metastasis (TNM) stages. This study built and verified a nomogram for predicting OS of TGCT patients, with higher clinical value compared to TNM stages. Our nomogram will assist clinicians in the appropriate management of patients with TGCTs.
期刊介绍：
The Indian Journal of Surgery is the official publication of the Association of Surgeons of India that considers for publication articles in all fields of surgery. Issues are published bimonthly in the months of February, April, June, August, October and December.
The journal publishes Original article, Point of technique, Review article, Case report, Letter to editor, Teachers and surgeons from the past - A short (up to 500 words) bio sketch of a revered teacher or surgeon whom you hold in esteem and Images in surgery, surgical pathology, and surgical radiology.
A trusted resource for peer-reviewed coverage of all types of surgery
Provides a forum for surgeons in India and abroad to exchange ideas and advance the art of surgery
The official publication of the Association of Surgeons of India
92% of authors who answered a survey reported that they would definitely publish or probably publish in the journal again
The Indian Journal of Surgery offers peer-reviewed coverage of all types of surgery. The Journal publishes Original articles, Points of technique, Review articles, Case reports, Letters, Images and brief biographies of influential teachers and surgeons.
The Journal spans General Surgery, Pediatric Surgery, Neurosurgery, Plastic Surgery, Cardiothoracic Surgery, Vascular Surgery, Rural Surgery, Orthopedic Surgery, Urology, Surgical Oncology, Radiology, Anaesthesia, Trauma Services, Minimal Access Surgery, Endocrine Surgery, GI Surgery, ENT, Colorectal Surgery, surgical practice and research.
The Journal provides a forum for surgeons from India and abroad to exchange ideas, to propagate the advancement of science and the art of surgery and to promote friendship among surgeons in India and abroad. This has been a trusted platform for surgons in communicating up-to-date scientific informeation to the community.
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