Application and prospect of Cu-based metal-organic frameworks in tumor therapy

Cancer has been one of the significant threats to human well-being in recent decades. Metal-organic frameworks (MOFs) are three-dimensional structural materials formulated of metal ions or metal clusters combined with polydentate organic moieties. They have controllable morphology, customizable diameter, adjustable porousness, elevated specific surface area, easy functionalization, and good biocompatibility. Many researchers have used MOFs' excellent and unique properties to design nano-platforms conducive to treating tumors. The present review summarizes the recent progress of copper-based MOF nanoplatforms for tumor treatment through different treatment stratgies, including chemotherapy, photothermal therapy, sonodynamic therapy and combined treatment methods and discusses the physiological mechanism and unique biological effects of copper(II)-based MOFs. Finally, we outlooked the current status of Cu-based MOFs in tumor therapy and prospect the changllent and potential development in anti-tumor in future.