延迟服用氯氮平导致耐药精神分裂症患者疗效更差

Q4 Medicine

Psiquiatria Biologica Pub Date : 2024-08-28 DOI:10.1016/j.psiq.2024.100493

Kalyani Rajalingham

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引用次数: 0

摘要

耐药性精神分裂症（TRS）是指精神分裂症患者对至少两种非氯氮平类抗精神病药物在适当剂量和适当时间内的治疗无效。TRS的典型治疗方法是氯氮平，但在使用氯氮平之前，患者会尝试多种替代疗法。目前的研究表明，使用氯氮平治疗 TRS 患者的疗效会随着时间的推移而降低；TRS 患者等待使用氯氮平的时间越长，疗效就可能越差。在本文中，笔者将对氯氮平的延迟治疗进行回顾；如果氯氮平治疗在最初 3 年内进行，则疗效显著。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clozapine delay results in poorer outcomes for treatment-resistant schizophrenia patients

Treatment-resistant schizophrenia (TRS) is a condition where schizophrenia patients do not respond to at least 2 non-clozapine anti-psychotics administered in proper dosage and for a proper period of time. The typical treatment for TRS is clozapine but many alternatives are attempted prior to administering clozapine. Current research shows that the effectiveness of treatment with clozapine decreases with time in TRS patients; the longer a TRS patient waits to use clozapine, the less effective it is likely to be. In this paper, I review clozapine delay; clozapine treatment is effective if it happens within the first 3 years.

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来源期刊

Psiquiatria Biologica Medicine-Psychiatry and Mental Health

CiteScore

0.40

自引率

0.00%

发文量

期刊介绍： Es la Publicación Oficial de la Sociedad Española de Psiquiatría Biológica. Los recientes avances en el conocimiento de la bioquímica y de la fisiología cerebrales y el progreso en general en el campo de las neurociencias han abierto el camino al desarrollo de la psiquiatría biológica, fundada sobre bases anatomofisiológicas, más sólidas y científicas que la psiquiatría tradicional.