从放线菌 Streptomyces sp.

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2024-09-12 DOI:10.1016/j.phytol.2024.08.002

Ming-Jen Cheng , Jih-Jung Chen , Hsia-Wei Liu , Jyh-Yih Leu , Ming-Der Wu , Min Tseng

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引用次数: 0

摘要

从放线菌 Streptomyces sp. BC129-2 培养液的乙酸乙酯可溶部分中分离出两种以前未曾描述过的化合物，包括一种苯基丙酮衍生物 BC129-2 (1) 和一种对孟烷类似物顺式对孟烷-7,8-二醇 (2)。在对光谱数据进行大量分析并与文献数据进行比较的基础上，阐明了所有分离物的结构。同时还对它们的抗真菌活性进行了评估。结果表明，其中 2 种成分（化合物 1 & 2）对镰刀菌 LC8、新孢子菌 BCRC 35002 和球孢子菌 Colletotrichum gloeosporioides BCRC 35178 具有温和的抗真菌活性。值得一提的是，对类型菌株链霉菌 BC129-2 的化学成分从未进行过研究。

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Isolation and antifungal activity assessment of natural compounds from the culture medium of actinobacterium Streptomyces sp. BC129-2

Two previously undescribed compounds, including one phenylpropanoid derivative, BC129–2 (1) and one p-menthane analogue, cis-p-menthane-7,8-diol (2), were isolated from the EtOAc-soluble fraction of the culture broth of an actinomycete Streptomyces sp. BC129–2. The structures of all isolates were elucidated on the basis of extensive analyses of spectroscopic data and comparison with literature data. Their antifungal activity was also evaluated. Our results showed that 2 constituents (compounds 1 & 2) possessed mild antifungal activity against Fusarium sp. LC8, Neopestalotiopsis sp. BCRC 35002, and Colletotrichum gloeosporioides BCRC 35178. It is worth mentioning that the chemical composition of the type strain Streptomyces sp. BC129–2 has never been studied.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.