{"title":"铜对台湾年轻人维生素 D 缺乏和肺功能下降之间的中介关系","authors":"","doi":"10.1016/j.ecoenv.2024.117034","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Vitamin D deficiency is prevalent worldwide and associated with worse outcomes in various lung diseases. This study examines the association between vitamin D deficiency and pulmonary function in healthy young adults.</p></div><div><h3>Methods</h3><p>This prospective cohort study (2017–2019) explored the impact of vitamin D deficiency on pulmonary function in a community-based young adult population. Pulmonary function was assessed via spirometry, with serum 25-hydroxyvitamin D [25(OH)D] and urinary copper levels quantified. Multivariate regression was used to estimate the relationship between vitamin D levels and lung function, with mediation analysis evaluating copper's role.</p></div><div><h3>Results</h3><p>The study included 1034 participants, average age 33.45 years, 41.93 % male. The median 25(OH)D level was 19.20 ng/mL (Interquartile Range: 13.48–24.90 ng/mL). Over half (54.74 %) had 25(OH)D levels below 20 ng/mL. Higher 25(OH)D levels were associated with better forced vital capacity (FVC) and forced expiratory volume in one second (FEV₁). Trends suggested subgroup differences, but these were not statistically significant, indicating a consistent effect of 25(OH)D on pulmonary function across groups. SEM analysis suggested urinary copper as a mediator between 25(OH)D levels and FVC.</p></div><div><h3>Conclusion</h3><p>Vitamin D deficiency is significantly associated with reduced pulmonary function in young adults in Taiwan.</p></div>","PeriodicalId":303,"journal":{"name":"Ecotoxicology and Environmental Safety","volume":null,"pages":null},"PeriodicalIF":6.2000,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0147651324011102/pdfft?md5=efcfd38f550b74cb44cebe0884597727&pid=1-s2.0-S0147651324011102-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Mediated relationship between Vitamin D deficiency and reduced pulmonary function by copper in Taiwanese young adults\",\"authors\":\"\",\"doi\":\"10.1016/j.ecoenv.2024.117034\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><p>Vitamin D deficiency is prevalent worldwide and associated with worse outcomes in various lung diseases. This study examines the association between vitamin D deficiency and pulmonary function in healthy young adults.</p></div><div><h3>Methods</h3><p>This prospective cohort study (2017–2019) explored the impact of vitamin D deficiency on pulmonary function in a community-based young adult population. Pulmonary function was assessed via spirometry, with serum 25-hydroxyvitamin D [25(OH)D] and urinary copper levels quantified. Multivariate regression was used to estimate the relationship between vitamin D levels and lung function, with mediation analysis evaluating copper's role.</p></div><div><h3>Results</h3><p>The study included 1034 participants, average age 33.45 years, 41.93 % male. The median 25(OH)D level was 19.20 ng/mL (Interquartile Range: 13.48–24.90 ng/mL). Over half (54.74 %) had 25(OH)D levels below 20 ng/mL. Higher 25(OH)D levels were associated with better forced vital capacity (FVC) and forced expiratory volume in one second (FEV₁). Trends suggested subgroup differences, but these were not statistically significant, indicating a consistent effect of 25(OH)D on pulmonary function across groups. SEM analysis suggested urinary copper as a mediator between 25(OH)D levels and FVC.</p></div><div><h3>Conclusion</h3><p>Vitamin D deficiency is significantly associated with reduced pulmonary function in young adults in Taiwan.</p></div>\",\"PeriodicalId\":303,\"journal\":{\"name\":\"Ecotoxicology and Environmental Safety\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.2000,\"publicationDate\":\"2024-09-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0147651324011102/pdfft?md5=efcfd38f550b74cb44cebe0884597727&pid=1-s2.0-S0147651324011102-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ecotoxicology and Environmental Safety\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0147651324011102\",\"RegionNum\":2,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ecotoxicology and Environmental Safety","FirstCategoryId":"93","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0147651324011102","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0
摘要
背景维生素 D 缺乏症在全球普遍存在,并与各种肺部疾病的恶化结果相关。本研究探讨了健康青壮年维生素 D 缺乏与肺功能之间的关系。方法这项前瞻性队列研究(2017-2019 年)探讨了维生素 D 缺乏对社区青壮年肺功能的影响。肺功能通过肺活量测定法进行评估,并对血清25-羟维生素D [25(OH)D]和尿铜水平进行量化。研究采用多元回归法估算维生素 D 水平与肺功能之间的关系,并通过中介分析评估铜的作用。25(OH)D水平中位数为19.20纳克/毫升(四分位距:13.48-24.90纳克/毫升)。一半以上(54.74%)的人 25(OH)D 水平低于 20 纳克/毫升。较高的 25(OH)D 水平与较好的用力肺活量(FVC)和一秒钟用力呼气容积(FEV₁)相关。趋势表明存在亚组差异,但这些差异在统计学上并不显著,表明 25(OH)D 对各组肺功能的影响是一致的。SEM 分析表明,尿铜是 25(OH)D 水平与 FVC 之间的中介因子。
Mediated relationship between Vitamin D deficiency and reduced pulmonary function by copper in Taiwanese young adults
Background
Vitamin D deficiency is prevalent worldwide and associated with worse outcomes in various lung diseases. This study examines the association between vitamin D deficiency and pulmonary function in healthy young adults.
Methods
This prospective cohort study (2017–2019) explored the impact of vitamin D deficiency on pulmonary function in a community-based young adult population. Pulmonary function was assessed via spirometry, with serum 25-hydroxyvitamin D [25(OH)D] and urinary copper levels quantified. Multivariate regression was used to estimate the relationship between vitamin D levels and lung function, with mediation analysis evaluating copper's role.
Results
The study included 1034 participants, average age 33.45 years, 41.93 % male. The median 25(OH)D level was 19.20 ng/mL (Interquartile Range: 13.48–24.90 ng/mL). Over half (54.74 %) had 25(OH)D levels below 20 ng/mL. Higher 25(OH)D levels were associated with better forced vital capacity (FVC) and forced expiratory volume in one second (FEV₁). Trends suggested subgroup differences, but these were not statistically significant, indicating a consistent effect of 25(OH)D on pulmonary function across groups. SEM analysis suggested urinary copper as a mediator between 25(OH)D levels and FVC.
Conclusion
Vitamin D deficiency is significantly associated with reduced pulmonary function in young adults in Taiwan.
期刊介绍:
Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.