UFMylation 在调节免疫反应中的新作用

IF 7.9 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Zhengyan Liang, Rongxuan Ning, Zhaoxiang Wang, Xia Kong, Yubin Yan, Yafei Cai, Zhiwei He, Xin-guang Liu, Yongkang Zou, Junzhi Zhou
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引用次数: 0

摘要

翻译后修饰是细胞功能蛋白的必经之路,最终调控着生命的几乎所有方面。泛素折叠修饰因子 1(Ubiquitin-fold modifier 1,UFM1)系统是一种新发现的泛素类修饰系统,具有不可或缺的生物学功能,其潜在的生物学机制在很大程度上仍未被发现。最近,该领域的研究迅速发展,揭示了 UFMylation 直接或间接调控多种免疫过程。在此,我们总结了 UFMylation 系统在特定生理或病理条件下如何响应内在和外在压力并保障免疫稳态的重要进展,为 UFMylation 系统的调控框架和功能及其在人类疾病中的治疗应用提供了新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The emerging roles of UFMylation in the modulation of immune responses

The emerging roles of UFMylation in the modulation of immune responses

Post-translational modification is a rite of passage for cellular functional proteins and ultimately regulate almost all aspects of life. Ubiquitin-fold modifier 1 (UFM1) system represents a newly identified ubiquitin-like modification system with indispensable biological functions, and the underlying biological mechanisms remain largely undiscovered. The field has recently experienced a rapid growth of research revealing that UFMylation directly or indirectly regulates multiple immune processes. Here, we summarised important advances that how UFMylation system responds to intrinsic and extrinsic stresses under certain physiological or pathological conditions and safeguards immune homeostasis, providing novel perspectives into the regulatory framework and functions of UFMylation system, and its therapeutic applications in human diseases.

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来源期刊
CiteScore
15.90
自引率
1.90%
发文量
450
审稿时长
4 weeks
期刊介绍: Clinical and Translational Medicine (CTM) is an international, peer-reviewed, open-access journal dedicated to accelerating the translation of preclinical research into clinical applications and fostering communication between basic and clinical scientists. It highlights the clinical potential and application of various fields including biotechnologies, biomaterials, bioengineering, biomarkers, molecular medicine, omics science, bioinformatics, immunology, molecular imaging, drug discovery, regulation, and health policy. With a focus on the bench-to-bedside approach, CTM prioritizes studies and clinical observations that generate hypotheses relevant to patients and diseases, guiding investigations in cellular and molecular medicine. The journal encourages submissions from clinicians, researchers, policymakers, and industry professionals.
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