封底外页:第 3 卷第 5 期

IF 24.5 Q1 CHEMISTRY, PHYSICAL
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引用次数: 0

摘要

封底外侧:doi:10.1002/idm2.12181的封面图片显示的是左股骨骨软骨缺损的放大视图,其中植入了三维生物打印双相支架。支架由软骨层(蓝色)和软骨下骨层(紫色)组成,采用多细胞生物打印技术制作。在软骨层中,含有关节软骨细胞(ACs,黄色)和骨髓间充质干细胞(BMSCs,红色)的GelMA相互作用,以维持ACs的表型并促进BMSC的软骨形成。在软骨下骨层,含有骨髓间充质干细胞的 GelMA/Sr-CSH(黄色纤维)释放出生物活性离子(Ca、Si、Sr),可增强骨髓间充质干细胞的成骨作用并刺激 ACs。GelMA 支持骨软骨界面重建。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Outside Back Cover: Volume 3 Issue 5

Outside Back Cover: Volume 3 Issue 5

Outside Back Cover: The cover image of doi:10.1002/idm2.12181 shows a magnified view of an osteochondral defect in the left femur with an implanted 3D-bioprinted biphasic scaffold. The scaffold consists of a cartilage layer (blue) and a subchondral bone layer (purple), created using multicellular bioprinting technology. In the cartilage layer, GelMA loaded with articular chondrocytes (ACs, yellow) and bone marrow mesenchymal stem cells (BMSCs, red) interacts to maintain the phenotype of ACs and promote BMSC chondrogenesis. In the subchondral bone layer, GelMA/Sr-CSH (yellow fibers) with BMSCs releases bioactive ions (Ca, Si, Sr) that enhance BMSC osteogenesis and stimulate ACs. GelMA supports osteochondral interface reconstruction.

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