{"title":"转录组分析发现 CCDC86 是一种新的潜在头颈部鳞状细胞癌生物标记物","authors":"Daniel Lee, Jules Gouron, Jules Gouron, Henrique Shimaoka Chagas, Bidhan Bhandari, Sahar Emami Naeini, Babak Baban, Pablo Shimaoka Chagas, Evila Salles","doi":"10.1016/j.dentre.2024.100105","DOIUrl":null,"url":null,"abstract":"<div><h3>OBJECTIVES</h3><p>Overall, this comprehensive analysis aims to evaluate the expression profile of CCDC86 in Head and Neck Squamous Cell Carcinoma, providing insights into its potential as a diagnostic biomarker.</p></div><div><h3>METHODS</h3><p>Initially, we conducted transcriptomic integration analysis to examine CCDC86 expression in HNSCC using various datasets (RNA-seq) obtained from the gene expression profiling interactive analysis database. We also established the diagnostic significance of CCDC86 and coregulated genes in HNSCC through the Kaplan–Meier Plotter.</p></div><div><h3>RESULTS</h3><p>Initially, we detected elevated levels of CCDC86 in HNSCC, which correlated with lower survival rates (p=<0.001). We also identified seven genes coregulated with CCDC86 that were also overexpressed in HNSCC in comparison with normal tissues.</p></div><div><h3>CONCLUSIONS</h3><p>For the first time, our findings suggest that CCDC86 can be a new emerging biomarker with promising therapeutic values to HNSCC patients.</p></div><div><h3>IMPLICATIONS</h3><p>No further implications other than specified in conclusion.</p></div>","PeriodicalId":100364,"journal":{"name":"Dentistry Review","volume":"4 3","pages":"Article 100105"},"PeriodicalIF":0.0000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772559624000282/pdfft?md5=38c1a1f72a7925c967bf13070598fd5e&pid=1-s2.0-S2772559624000282-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Transcriptome analysis identifies CCDC86 as a new potential Head and Neck Squamous Cell Carcinoma biomarker\",\"authors\":\"Daniel Lee, Jules Gouron, Jules Gouron, Henrique Shimaoka Chagas, Bidhan Bhandari, Sahar Emami Naeini, Babak Baban, Pablo Shimaoka Chagas, Evila Salles\",\"doi\":\"10.1016/j.dentre.2024.100105\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>OBJECTIVES</h3><p>Overall, this comprehensive analysis aims to evaluate the expression profile of CCDC86 in Head and Neck Squamous Cell Carcinoma, providing insights into its potential as a diagnostic biomarker.</p></div><div><h3>METHODS</h3><p>Initially, we conducted transcriptomic integration analysis to examine CCDC86 expression in HNSCC using various datasets (RNA-seq) obtained from the gene expression profiling interactive analysis database. We also established the diagnostic significance of CCDC86 and coregulated genes in HNSCC through the Kaplan–Meier Plotter.</p></div><div><h3>RESULTS</h3><p>Initially, we detected elevated levels of CCDC86 in HNSCC, which correlated with lower survival rates (p=<0.001). We also identified seven genes coregulated with CCDC86 that were also overexpressed in HNSCC in comparison with normal tissues.</p></div><div><h3>CONCLUSIONS</h3><p>For the first time, our findings suggest that CCDC86 can be a new emerging biomarker with promising therapeutic values to HNSCC patients.</p></div><div><h3>IMPLICATIONS</h3><p>No further implications other than specified in conclusion.</p></div>\",\"PeriodicalId\":100364,\"journal\":{\"name\":\"Dentistry Review\",\"volume\":\"4 3\",\"pages\":\"Article 100105\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2772559624000282/pdfft?md5=38c1a1f72a7925c967bf13070598fd5e&pid=1-s2.0-S2772559624000282-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dentistry Review\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2772559624000282\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dentistry Review","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772559624000282","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Transcriptome analysis identifies CCDC86 as a new potential Head and Neck Squamous Cell Carcinoma biomarker
OBJECTIVES
Overall, this comprehensive analysis aims to evaluate the expression profile of CCDC86 in Head and Neck Squamous Cell Carcinoma, providing insights into its potential as a diagnostic biomarker.
METHODS
Initially, we conducted transcriptomic integration analysis to examine CCDC86 expression in HNSCC using various datasets (RNA-seq) obtained from the gene expression profiling interactive analysis database. We also established the diagnostic significance of CCDC86 and coregulated genes in HNSCC through the Kaplan–Meier Plotter.
RESULTS
Initially, we detected elevated levels of CCDC86 in HNSCC, which correlated with lower survival rates (p=<0.001). We also identified seven genes coregulated with CCDC86 that were also overexpressed in HNSCC in comparison with normal tissues.
CONCLUSIONS
For the first time, our findings suggest that CCDC86 can be a new emerging biomarker with promising therapeutic values to HNSCC patients.
IMPLICATIONS
No further implications other than specified in conclusion.
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