白色念珠菌逃避宿主免疫的隐形策略

IF 20.6 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2024-09-11 DOI:10.1016/j.chom.2024.08.005

Yebo Gu, Xin-Ming Jia

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引用次数: 0

摘要

在机会性致病过程中，白色念珠菌会采用经典策略，如酵母到芽孢的转化和免疫原性掩蔽。在本期《细胞宿主与amp; 微生物》（Cell Host & Microbe）杂志上，Luo 等人揭示了效应蛋白 Cmi1 可转运到宿主细胞内并靶向 TBK1，从而负向调节宿主的抗真菌免疫反应。

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Stealth strategies of Candida albicans to evade host immunity

During opportunistic pathogenic episodes, Candida albicans employs classical strategies such as the yeast-to-hyphae transition and immunogenic masking. In this issue of Cell Host & Microbe, Luo et al. unveil that the effector protein Cmi1 can be translocated into host cells and targets TBK1, thereby negatively regulating the host’s antifungal immune responses.

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.