宿主与肠道微生物群之间的对话揭示了化疗的 "银弹 "治疗方案

IF 20.6 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2024-09-11 DOI:10.1016/j.chom.2024.08.008

Mengdan Zhang, Hao Guo

引用次数: 0

摘要

化疗与诱导肠道微生物群失调和胃肠道损伤有关。在本期的《细胞-宿主-微生物》（Cell Host & Microbe）杂志中，Anderson 等人证明化疗诱导的上皮细胞凋亡会导致微生物群失衡和转录重构，进而延迟肠道恢复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Conversation between host and gut microbiota unveils a “silver bullet” therapeutic option for chemotherapy

Chemotherapy is associated with the induction of intestinal microbiota dysbiosis and gastrointestinal injuries. In this Cell Host & Microbe issue, Anderson et al. demonstrate that chemotherapy-induced epithelial cell apoptosis drives microbiota imbalance and transcriptional rewiring, which in turn delays intestinal recovery.

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.