细胞外囊泡分析科学失去了创造力和亲切感

IF 15.5 1区 医学 Q1 CELL BIOLOGY
Paolo Bergese, Marcella Chiari, Alessandro Gori, Benedetta Bussolati, Pietro Parisse, the EVIta Board
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Her interest in the field was raised by participating in the EU project INDEX, coordinated by Dr Marcella Chiari, and became true love for this fascinating and challenging area. This led Marina to establish her own research team and to find the Extracellular Vesicle Lab at SCITEC-CNR. Soon after, she was the Coordinator of the EU project MARVEL, a multi-partner project at the intersection of chemistry and technology, biology and translational medicine, which was centred around the use of membrane-sensing peptides (MSP) as enabling tools for the multiscale EV isolation (Gori et al., <span>2020</span>, Gori et al, <span>2024</span>). She was a true pioneer in this field and she consolidated a leading expertise in the area of ultrasensitive EV analysis, aiming to fill existing gaps in the clinical translation of EVs in diagnostics. 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引用次数: 0

摘要

然而,人们记住她的不仅仅是她的科学贡献,还有她的善良、慷慨、可靠以及她对所有有幸认识她的人产生的积极影响。玛丽娜是敬业和专业精神的典范,是激励我们所有人的灯塔和基石。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Extracellular vesicle analytical science loses a touch of creativity and kindness

It is with profound sadness and sorrow that we announce the unexpected passing of our cherished friend and colleague, Marina Cretich. Marina, a renowned scientist in the field of bioanalytical chemistry, passed away on June 29th 2024, leaving behind a heritage of invaluable contributions to science. Her career was marked by a relentless pursuit of knowledge and an unwavering dedication to advancing scientific understanding.

Marina graduated in Biological Sciences with a specialization in Molecular Biology from the University of Milano in 1998 with Prof. Piergiorgio Righetti. She then joined the National Research Council of Italy (CNR), where she served as a Researcher at the Institute of Chemistry for Molecular Recognition in Milan, becoming a key figure in the Analytical Microsystem laboratory guided by Dr. Marcella Chiari. Thanks to the interdisciplinarity of her approach, she made significant strides in the progress of advanced methods and materials for bio-molecular recognition, together with high-sensitive and selective biosensors, providing new tools for detecting biomolecules with unprecedented accuracy and efficiency. Her strong focus on integrating bioanalytical techniques, microfluidics and detection tools, enabled more rapid and precise analyses, enhancing the capabilities of lab-on-a-chip devices, towards point-of-care diagnostics.

These studies paved the road to her approach to extracellular vesicles, addressing the challenges posed by their separation and analysis. Specifically, Marina was working on affinity-capturing protocols from complex samples for EV isolation and on microarray platforms for their molecular characterization (Daaboul et al., 2016). Her interest in the field was raised by participating in the EU project INDEX, coordinated by Dr Marcella Chiari, and became true love for this fascinating and challenging area. This led Marina to establish her own research team and to find the Extracellular Vesicle Lab at SCITEC-CNR. Soon after, she was the Coordinator of the EU project MARVEL, a multi-partner project at the intersection of chemistry and technology, biology and translational medicine, which was centred around the use of membrane-sensing peptides (MSP) as enabling tools for the multiscale EV isolation (Gori et al., 2020, Gori et al, 2024). She was a true pioneer in this field and she consolidated a leading expertise in the area of ultrasensitive EV analysis, aiming to fill existing gaps in the clinical translation of EVs in diagnostics. Her contribution is witnessed by remarkable scientific contributions (Frigerio et al., 2022; Musicò et al., 2024) and, despite very recent, the concepts and technologies that she developed set the basis for an ever-increasing number of preclinical and clinical collaborations encompassing EV analysis in the fields of neurodegeneration, cancer, and heart diseases.

In recent years, she also dedicated herself to the translation of the analytical equipment she developed to support new explorations of the nanostructured secretome landscape. For example, she participated in opening the path to the study of the EV biomolecular corona, which is determined by the interaction between EVs with the repertoire of biomolecules and other extracellular nanoparticles (e.g., lipoproteins) populating biological fluids, and has been shown to be crucial in determining key physicochemical properties and functions of EVs (Musicò et al., 2024; Ridolfi et al., 2023).

The international positioning achieved by Marina in the field of EVs is also witnessed by numerous invited seminars, oral communications and activities conducted within the framework of the ISEV community. It is worth highlighting her lectures at the Education Day of the annual ISEV meeting in 2022 on Single Vesicle Analysis techniques, and in 2024 during the Workshop “Tiny Packages Big Impact” at the University of Virginia, Charlottesville. She was also Co-Chair of the ISEV workshop “QuantitatEVs (J. Extracell. Biol. 2024;3:e137”) and contributing author of the “Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches”. At the national level, she was amongst the founders of the Italian Society for Extracellular Vesicles (EVIta), and elected member of the EVIta Board since 2022. She was also a promoter of a multi-department initiative within the National Research Council of Italy (CNR-EV-NET: Joining forces in the study of Extracellular Vesicles).

Beyond her scientific achievements, Marina was a beloved mentor and colleague. She dedicated herself to students, nurturing their talents and guiding their research endeavours. Her commitment to education and her ability to inspire young scientists will be remembered as one of her most significant legacies.

Marina's passing is a profound loss to the scientific community because of her brilliance, dedication, and profound love for the pursuit of knowledge. However, she will be remembered not only for her scientific contributions, but also for her kindness, generosity, reliability, and the positive impact she had on all who had the privilege of knowing her. Marina exemplified dedication and professionalism, serving as a beacon of inspiration and a cornerstone for us all.

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来源期刊
Journal of Extracellular Vesicles
Journal of Extracellular Vesicles Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
27.30
自引率
4.40%
发文量
115
审稿时长
12 weeks
期刊介绍: The Journal of Extracellular Vesicles is an open access research publication that focuses on extracellular vesicles, including microvesicles, exosomes, ectosomes, and apoptotic bodies. It serves as the official journal of the International Society for Extracellular Vesicles and aims to facilitate the exchange of data, ideas, and information pertaining to the chemistry, biology, and applications of extracellular vesicles. The journal covers various aspects such as the cellular and molecular mechanisms of extracellular vesicles biogenesis, technological advancements in their isolation, quantification, and characterization, the role and function of extracellular vesicles in biology, stem cell-derived extracellular vesicles and their biology, as well as the application of extracellular vesicles for pharmacological, immunological, or genetic therapies. The Journal of Extracellular Vesicles is widely recognized and indexed by numerous services, including Biological Abstracts, BIOSIS Previews, Chemical Abstracts Service (CAS), Current Contents/Life Sciences, Directory of Open Access Journals (DOAJ), Journal Citation Reports/Science Edition, Google Scholar, ProQuest Natural Science Collection, ProQuest SciTech Collection, SciTech Premium Collection, PubMed Central/PubMed, Science Citation Index Expanded, ScienceOpen, and Scopus.
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