Single-Administration Self-Boosting Microneedle Patch for the Treatment of Obesity (Adv. Therap. 9/2024)

GLP-1 RAs are effective therapies for obesity which affects 70% of American adults. However, frequent subcutaneous injections pose challenges for patients and the environment. Here, a programmable scheduled microneedle system is introduced, delivering Semaglutide instantaneously and longitudinally over a month with one skin patch administration. This sustains the drug efficacy and addresses common issues of traditional administration using multiple injections such as pain, needle phobia, high cost and the need of medical personnel, ensuring effective obesity management. More details can be found in article 2400028 by Thanh Duc Nguyen and co-workers.