水飞蓟素对氯化钙诱发雄性大鼠心律失常的影响

2区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Oxidative Medicine and Cellular Longevity Pub Date : 2024-08-31 eCollection Date: 2024-01-01 DOI:10.1155/2024/6720138
Fereshteh Toghroli, Mohammad Foad Noorbakhsh, Javad Sajedianfard
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引用次数: 0

摘要

抗氧化剂在保护心律失常方面发挥着重要作用。水飞蓟素是一种强抗氧化剂,能有效减少心律失常引起的并发症。本研究旨在确定水飞蓟素对氯化钙诱发的心律失常的预防和治疗效果。共将 48 只雄性大鼠随机分为 6 组:第一组为急性给药对照组,静脉注射 0.2 mL二甲基亚砜(一种助溶剂)静脉注射;第二对照组为慢性给药组,在诱发心律失常前 2 周内每天灌胃二甲基亚砜;急性水飞蓟素组在心律失常发生后立即静脉注射 100 mg/kg;慢性水飞蓟素组,在诱发心律失常前 2 周,每天灌胃 50 毫克/千克;胺碘酮标准疗法,在诱发心律失常后立即静脉注射 5 毫克/千克;奎尼丁标准疗法,在诱发心律失常后立即静脉注射 10 毫克/千克。氯化钙(140 毫克/千克,静脉注射)用于诱发心律失常。心电图由 PowerLab™ 系统记录和监测。计算室性早搏(PVB)、室性心动过速(VT)和室颤(VF)的发生率。与对照组(100%)相比,水飞蓟素的抗心律失常效果显著,室性早搏(22.56 ± 1.04%,P < 0.001)、室性心动过速(34.150 ± 1.59%,P < 0.001)和心室颤动(24.31 ± 1.02%,P < 0.001)的发生率明显降低。这些效果与奎尼丁(29.23% ± 1.24%,52.23% ± 1.13%,66.31% ± 1.81%)和胺碘酮(22.91% ± .72%,41.09% ± 1.66%,61.59% ± 1.11%)等抗心律失常药物相当。水飞蓟素具有强大的抗氧化作用,从而降低了发生 VT、VF 和 PVC 的风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effects of Silymarin on Calcium Chloride-Induced Arrhythmia in Male Rat.

Antioxidants play an important role in protecting cardiac arrhythmias. Silymarin, strong antioxidant, is effective in reducing the complications caused by arrhythmias. This study was conducted to determine the effect of silymarin on the prevention and treatment of calcium chloride-induced arrhythmia. In total, 48 male rats were randomly divided into six groups: the first control group for acute administration received intravenous injection of 0.2 mL of dimethylsulfoxide, a cosolvent, immediately after induction of arrhythmia; the second control group for chronic administration, daily gavage of dimethylsulfoxide for 2 weeks before induction of arrhythmia; acute silymarin group, 100 mg/kg intravenous, immediately after the occurrence of arrhythmia; chronic silymarin group, daily gavage of 50 mg/kg for 2 weeks before induction of arrhythmia; amiodarone standard treatment, 5 mg/kg intravenous, immediately after induction of arrhythmia; and quinidine standard treatment, 10 mg/kg intravenous, immediately after induction of arrhythmia. Calcium chloride (140 mg/kg, i.v.) was used to induce arrhythmia. Electrocardiogram was recorded and monitored by PowerLab™ system. The incidence rates of premature ventricular beat (PVB), ventricular tachycardia (VT), and ventricular fibrillation (VF) were calculated. The antiarrhythmic effect of silymarin was observed with a significant decrease in the incidence of premature ventricular beat (22.56 ± 1.04%, P < 0.001), ventricular tachycardia (34.150 ± 1.59%, P < 0.001), and ventricular fibrillation (24.31 ± 1.02%, P < 0.001) compared with the control group (100%). These effects were comparable to antiarrhythmic drugs such as quinidine (29.23% ± 1.24%, 52.23% ± 1.13%, 66.31% ± 1.81%) and amiodarone (22.91% ± .72%, 41.09% ± 1.66%, 61.59% ± 1.11%). Silymarin exerts a potent antioxidant effect, thereby mitigating the risk of VT, VF, and PVC.

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来源期刊
CiteScore
13.20
自引率
0.00%
发文量
1274
审稿时长
3-8 weeks
期刊介绍: Oxidative Medicine and Cellular Longevity is a unique peer-reviewed, Open Access journal that publishes original research and review articles dealing with the cellular and molecular mechanisms of oxidative stress in the nervous system and related organ systems in relation to aging, immune function, vascular biology, metabolism, cellular survival and cellular longevity. Oxidative stress impacts almost all acute and chronic progressive disorders and on a cellular basis is intimately linked to aging, cardiovascular disease, cancer, immune function, metabolism and neurodegeneration. The journal fills a significant void in today’s scientific literature and serves as an international forum for the scientific community worldwide to translate pioneering “bench to bedside” research into clinical strategies.
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