钙化性肌坏死导致的行动不便：威尔逊氏病罕见但可逆的并发症。

IF 1.9 4区医学 Q3 CLINICAL NEUROLOGY

Annals of Indian Academy of Neurology Pub Date : 2024-11-01 Epub Date: 2024-09-09 DOI:10.4103/aian.aian_419_24

Abhishek Vaingankar, Divyani Garg, Ayush Agarwal, Divya M Radhakrishnan, Awadh Kishor Pandit, Madhavi Tripathi, Achal K Srivastava

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引用次数: 0

摘要

摘要：我们报告了两例已确诊的威尔逊氏病（WD）病例，患者骨盆腰部钙化性肌坏死，并伴有骨盆骨折。尽管最初经过螯合治疗后病情有所好转，但这两个病例的行走能力在亚急性期均出现恶化，因此考虑螯合治疗会导致神经功能恶化。然而，评估结果显示，髋关节和邻近肌肉的钙化性肌坏死才是病因。经过强化康复治疗，两名患者的病情均有好转。文献综述表明，虽然有报道称髋关节脱位会出现骨肌肉并发症，但钙化性肌坏死是迄今为止未知的一种情况，如果能及早发现，就有可能逆转，从而避免残疾和不必要地改变螯合疗法。

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Loss of Ambulation Due to Calcific Myonecrosis: A Rare but Reversible Complication of Wilson's Disease.

We report two cases of established Wilson's disease (WD) presenting with calcific myonecrosis of the pelvic girdle in association with pelvic fractures. Despite initial improvement with chelation, subacute worsening of ambulation in both led to a consideration of neurologic deterioration on chelation therapy. However, evaluation revealed calcific myonecrosis of the hip joint and adjacent muscles as the cause. Both patients improved with intensive rehabilitation. A review of literature indicates that although osseomuscular complications are reported in WD, calcific myonecrosis is a hitherto unknown entity which, if recognized early, may be reversed, preventing disability and unnecessary change in chelation regimens.

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来源期刊

Annals of Indian Academy of Neurology Nervous System Diseases-

CiteScore

2.20

自引率

11.80%

发文量

293

审稿时长

29 weeks

期刊介绍： The journal has a clinical foundation and has been utilized most by clinical neurologists for improving the practice of neurology. While the focus is on neurology in India, the journal publishes manuscripts of high value from all parts of the world. Journal publishes reviews of various types, original articles, short communications, interesting images and case reports. The journal respects the scientific submission of its authors and believes in following an expeditious double-blind peer review process and endeavors to complete the review process within scheduled time frame. A significant effort from the author and the journal perhaps enables to strike an equilibrium to meet the professional expectations of the peers in the world of scientific publication. AIAN believes in safeguarding the privacy rights of human subjects. In order to comply with it, the journal instructs all authors when uploading the manuscript to also add the ethical clearance (human/animals)/ informed consent of subject in the manuscript. This applies to the study/case report that involves animal/human subjects/human specimens e.g. extracted tooth part/soft tissue for biopsy/in vitro analysis.