评估阿尼芬净治疗肥胖住院重症患者念珠菌血症的临床疗效：一项多中心回顾性队列研究。

IF 4.8 2区医学 Q1 INFECTIOUS DISEASES

International Journal of Infectious Diseases Pub Date : 2024-09-04 DOI:10.1016/j.ijid.2024.107234

Yazed Saleh Alsowaida , Khalid Al Sulaiman , Ahmad J. Mahrous , Aisha Alharbi , Nisrin Bifari , Walaa A. Alshahrani , Thamer A. Almangour , Nader Damfu , Aseel A. Banamah , Raghad R. Abu Raya , Raghad A. Sadawi , Arwa Alharbi , Ahmed Alsolami , Yahya Essa , Alaa Ghaze Almagthali , Shahad F. Alhejaili , Wed A. Qawwas , Ghaida Salamah Alharbi , Atheer Suleiman Alkeraidees , Afnan Alshomrani , Ohoud Aljuhani

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引用次数: 0

摘要

目的评估阿尼芬净治疗肥胖重症患者念珠菌病的临床疗效：方法：在沙特阿拉伯开展了一项多中心回顾性队列研究，研究对象为接受阿尼芬净治疗的成人念珠菌病重症患者。肥胖患者的体重指数≥30 kg/m2。主要结果是临床治愈率：结果：共纳入 146 例患者，其中 64 例为肥胖患者。与非肥胖患者相比，肥胖患者的临床治愈率（P=0.63）、微生物治愈率（P=0.27）或临床治愈的中位时间（P=0.13）均无统计学差异。非肥胖患者微生物治愈的中位时间长于肥胖患者（P=0.04）。肥胖患者的中位住院时间（LOS）和中位机械通气时间（MV）在数字上更长：结论：两组患者的临床和微生物治愈率以及临床治愈时间在统计学上相似。考虑到研究的局限性（尤其是样本量较小），肥胖患者的疗效是否与非肥胖患者相似尚不确定。今后有必要进行样本量更大的研究，以评估肥胖是否会对阿尼芬净治疗念珠菌病的临床疗效产生负面影响。

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Evaluation of clinical outcomes of anidulafungin for the treatment of candidemia in hospitalized critically ill patients with obesity: A multicenter, retrospective cohort study

Objectives

To evaluate the clinical outcomes of anidulafungin for candidemia treatment in critically ill patients with obesity.

Methods

A multicenter, retrospective cohort study was conducted in Saudi Arabia for critically ill adults with candidemia who received anidulafungin. Patients with obesity have a body mass index ≥30 kg/m². The primary outcome was the clinical cure rate.

Results

A total of 146 patients were included, 64 of whom were obese. There were no statistically significant differences in the clinical cure rate (P = 0.63), microbiological cure rate (P = 0.27), or the median time for a clinical cure (P = 0.13) for patients with obesity compared to non-obese patients. The median time for a microbiological cure was longer in non-obese patients than in patients with obesity (P = 0.04). The median hospital length of stay and the median mechanical ventilation durations were numerically longer in patients with obesity.

Conclusions

Clinical and microbiological cure rates and time for clinical cure were statistically similar for both groups. Considering the study's limitations (especially with a small sample size), it is uncertain if patients with obesity have similar effectiveness to non-obese patients. Future studies with larger sample sizes are warranted to evaluate if obesity negatively impacts anidulafungin's clinical outcomes for candidemia.

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来源期刊

International Journal of Infectious Diseases 医学-传染病学

CiteScore

18.90

自引率

2.40%

发文量

1020

审稿时长

30 days

期刊介绍： International Journal of Infectious Diseases (IJID) Publisher: International Society for Infectious Diseases Publication Frequency: Monthly Type: Peer-reviewed, Open Access Scope: Publishes original clinical and laboratory-based research. Reports clinical trials, reviews, and some case reports. Focuses on epidemiology, clinical diagnosis, treatment, and control of infectious diseases. Emphasizes diseases common in under-resourced countries.