脊髓损伤后神经血管中的铁蛋白沉积。

IF 4.6 2区医学 Q1 NEUROSCIENCES

Experimental Neurology Pub Date : 2024-09-04 DOI:10.1016/j.expneurol.2024.114943

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引用次数: 0

摘要

脊髓损伤后的继发性损伤机制十分复杂。铁凋亡是神经血管单元（NVU）中一种新发现的调节性细胞死亡形式，其作用日益重要。研究表明，铁凋亡抑制剂可改善神经血管稳态，减轻继发性脊髓损伤（SCI）。这篇综述将根据 SCI 的不同阶段，重点探讨 NVU 细胞的铁凋亡机制和 NVU 靶向治疗策略，并分析未来可能的研究方向。

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Ferroptosis in the neurovascular unit after spinal cord injury

The mechanisms of secondary injury following spinal cord injury are complicated. The role of ferroptosis, which is a newly discovered form of regulated cell death in the neurovascular unit(NVU), is increasingly important. Ferroptosis inhibitors have been shown to improve neurovascular homeostasis and attenuate secondary spinal cord injury(SCI). This review focuses on the mechanisms of ferroptosis in NVU cells and NVU-targeted therapeutic strategies according to the stages of SCI, and analyzes possible future research directions.

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来源期刊

Experimental Neurology 医学-神经科学

CiteScore

10.10

自引率

3.80%

发文量

258

审稿时长

42 days

期刊介绍： Experimental Neurology, a Journal of Neuroscience Research, publishes original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity and transplantation. The journal has focused on research concerning basic mechanisms underlying neurological disorders.