运动表现与健康:GLUT4‡ 的作用。

IF 7.1 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
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引用次数: 0

摘要

葡萄糖转运体 GLUT4 是运动时骨骼肌发挥最佳性能以及新陈代谢健康不可或缺的物质。运动过程中 GLUT4 转位的生理调节和运动后 GLUT4 表达的增加涉及多种冗余信号通路。其中包括活性氧(ROS)的影响。ROS 可促进 GLUT4 转位,从而在运动过程中增加骨骼肌的葡萄糖吸收,并刺激信号通路,增加 GLUT4 的表达。相反,在代谢性疾病状态下,ROS 也会抑制 GLUT4 的转运和表达。ROS 在 GLUT4 调节中的相反作用最终与骨骼肌的新陈代谢状态相关联,其中错综复杂的机制让人们深入了解了对运动表现至关重要并与新陈代谢健康和疾病有关的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Exercise performance and health: Role of GLUT4

Exercise performance and health: Role of GLUT4

The glucose transporter GLUT4 is integral for optimal skeletal muscle performance during exercise, as well as for metabolic health. Physiological regulation of GLUT4 translocation during exercise and increased GLUT4 expression following exercise involves multiple, redundant signalling pathways. These include effects of reactive oxygen species (ROS). ROS contribute to GLUT4 translocation that increases skeletal muscle glucose uptake during exercise and stimulate signalling pathways that increase GLUT4 expression. Conversely, ROS can also inhibit GLUT4 translocation and expression in metabolic disease states. The opposing roles of ROS in GLUT4 regulation are ultimately linked to the metabolic state of skeletal muscle and the intricate mechanisms involved give insights into pathways critical for exercise performance and implicated in metabolic health and disease.

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来源期刊
Free Radical Biology and Medicine
Free Radical Biology and Medicine 医学-内分泌学与代谢
CiteScore
14.00
自引率
4.10%
发文量
850
审稿时长
22 days
期刊介绍: Free Radical Biology and Medicine is a leading journal in the field of redox biology, which is the study of the role of reactive oxygen species (ROS) and other oxidizing agents in biological systems. The journal serves as a premier forum for publishing innovative and groundbreaking research that explores the redox biology of health and disease, covering a wide range of topics and disciplines. Free Radical Biology and Medicine also commissions Special Issues that highlight recent advances in both basic and clinical research, with a particular emphasis on the mechanisms underlying altered metabolism and redox signaling. These Special Issues aim to provide a focused platform for the latest research in the field, fostering collaboration and knowledge exchange among researchers and clinicians.
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