2017 年至 2023 年在三级医疗中心进行的低滴度血清隐球菌抗原检测的意义。

IF 2.7 3区医学 Q3 INFECTIOUS DISEASES

Medical mycology Pub Date : 2024-09-06 DOI:10.1093/mmy/myae093

Thein Myint, Jenna R Wilson, Mahesh Bhatt, Mark E Irwin, Julie A Ribes

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引用次数: 0

摘要

2016年末，我们所在的三级甲等医院发现了几例血清隐球菌抗原（SCrAg）侧流测定法（LFA）的低血清隐球菌抗原（SCrAg）假阳性报告。在召回并纠正试剂中的问题后，我们研究了 2017 年 1 月至 2023 年 10 月期间 SCrAg LFA ≤ 1:10 的意义。在20名患者的31份SCrAg LFA≤1:10的样本中，14名患者（70%）被归类为真阳性，4名患者（20%）为不确定，只有2名患者（10%）为假阳性。如果检测到新的 SCrAg LFA ≤1:10，则应重复检测，并继续进行其他检查。

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The significance of low titer serum cryptococcal antigen testing from 2017 to 2023 performed in a tertiary care center.

Several false positive low serum cryptococcal antigen (SCrAg) reports by lateral flow assay (LFA) were identified in late 2016 at our tertiary care hospital. After the recall and correction of the problem in the reagent, we studied the significance of SCrAg LFA ≤ 1:10 from January 2017 to October 2023. Of 20 patients with 31 samples of SCrAg LFA ≤ 1:10, 14 patients (70%) were classified as true positives, four (20%) were indeterminate, and only two (10%) patients were false positives. If a new SCrAg LFA ≤ 1:10 is detected, it should be repeated, and additional workup should be pursued.

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来源期刊

Medical mycology 医学-兽医学

CiteScore

5.70

自引率

3.40%

发文量

632

审稿时长

12 months

期刊介绍： Medical Mycology is a peer-reviewed international journal that focuses on original and innovative basic and applied studies, as well as learned reviews on all aspects of medical, veterinary and environmental mycology as related to disease. The objective is to present the highest quality scientific reports from throughout the world on divergent topics. These topics include the phylogeny of fungal pathogens, epidemiology and public health mycology themes, new approaches in the diagnosis and treatment of mycoses including clinical trials and guidelines, pharmacology and antifungal susceptibilities, changes in taxonomy, description of new or unusual fungi associated with human or animal disease, immunology of fungal infections, vaccinology for prevention of fungal infections, pathogenesis and virulence, and the molecular biology of pathogenic fungi in vitro and in vivo, including genomics, transcriptomics, metabolomics, and proteomics. Case reports are no longer accepted. In addition, studies of natural products showing inhibitory activity against pathogenic fungi are not accepted without chemical characterization and identification of the compounds responsible for the inhibitory activity.