黄酮类化合物作为心肌缺血再灌注损伤的疗法:临床前研究综述。

IF 2.7 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Vipin Kumar Verma, Priya Bhardwaj, Vaishali Prajapati, Avantika Bhatia, Sayani Purkait, Dharamvir Singh Arya
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引用次数: 0

摘要

缺血性心脏病是全球最常见的死亡原因,影响着所有年龄组的男女老少。高死亡率是由于心肌缺血和再吸氧时造成的心肌组织损伤,因此避免再灌注损伤被认为是减少急性心脏损伤和随后死亡率的潜在方法。黄酮类化合物是源自植物的多酚衍生物,大量经验证据证实了它们的多种活性,如抗氧化、抗炎、抗细胞凋亡和抗血栓形成等,从而使它们在保护心脏方面发挥作用。最近的研究揭示了类黄酮阻碍关键调节酶、信号分子和转录因子的能力,而这些调节酶、信号分子和转录因子正是参与炎症级联反应的介质。本综述详述了从 2007 年到 2023 年有关类黄酮在预防和治疗心肌缺血再灌注损伤方面有效性的临床前研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Flavonoids as therapeutics for myocardial ischemia-reperfusion injury: a comprehensive review on preclinical studies.

Ischemic heart disease is the most prevalent cause of death worldwide affecting both the gender of all age groups. The high mortality rate is due to damage of myocardial tissue that emanates at the time of myocardial ischemia and re-oxygenation, thus averting reperfusion injury is recognized as a potential way to reduce acute cardiac injury and subsequent mortality. Flavonoids are polyphenol derivatives of plant origin and empirical shreds of evidence substantiate their numerous activities such as antioxidant, anti-inflammatory, anti-apoptotic, and anti-thrombotic activity, leading to their role in cardio protection. Recent investigations have unveiled the capacity of flavonoids to impede pivotal regulatory enzymes, signaling molecules, and transcription factors that orchestrate the mediators participating in the inflammatory cascade. The present comprehensive review, dwells on the preclinical studies on the effectiveness of flavonoids from the year 2007 to 2023, for the prevention and therapeutics for myocardial ischemia-reperfusion injury.

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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
32
审稿时长
8 weeks
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