通过注射用聚乙二醇配制的酪胺增强万年青的免疫力和抗病性。

IF 2.7 3区 农林科学 Q1 FISHERIES
Cheng-Ying Li , Hsin-Wei Kuo , Winton Cheng
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引用次数: 0

摘要

本研究调查了通过施用与聚乙二醇(PEG)配制的酪胺(TA)对南美白对虾免疫抗病性的延长效果。面对集约化养殖、环境压力和全球气候变化的挑战,采用创新方法改善对虾健康至关重要。研究重点是生物胺在应激反应和免疫调节中的作用,结果表明,TA(尤其是与 PEG 结合使用时)能显著延长免疫力,增强对藻类溶解弧菌的抵抗力。实验设计包括施用 TA、PEG 和 TA-PEG,然后评估免疫力、乳酸和葡萄糖水平以及免疫相关基因的表达。结果显示,TA-PEG 组的血细胞总数、酚氧化酶活性和吞噬细胞活性明显延长,表明免疫激活期延长。此外,TA-PEG 组的丙醇氧化酶系统相关基因表达明显上调。此外,TA-PEG 组在对溶藻病毒的敏感性测试中存活率明显更高。本研究结果证实,联合使用 PEG 可有效延长 TA 的免疫刺激持续时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Enhancement of immunity and disease resistance in Litopenaeus vannamei through injection of tyramine formulated with polyethylene glycol

This study investigates the prolonged effect of immune disease resistance in Litopenaeus vannamei through the administration of tyramine (TA) formulated with polyethylene glycol (PEG). Facing the challenges of intensive farming, environmental stress, and global climate changes, innovative approaches to improve shrimp health are essential. The research focuses on the role of biogenic amines in stress response and immune regulation, demonstrating that TA, especially when combined with PEG, significantly prolongs immunity and resistance against Vibrio alginolyticus. The experimental design included administering TA, PEG, and TA-PEG, followed by evaluations of immunity, lactate and glucose levels, and immune-related gene expressions. Results showed notable prolonged effects in total hemocyte count, phenoloxidase activity, and phagocytic activity in the TA-PEG group, indicating enhanced immune activation period. Additionally, the expression of prophenoloxidase system-related genes was significantly upregulated in the TA-PEG group. Furthermore, the TA-PEG group exhibited a significantly higher survival rate in a susceptibility test against V. alginolyticus. The results of this study confirm that the combined use of PEG can effectively extend the immunostimulatory duration of TA.

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来源期刊
CiteScore
6.20
自引率
6.90%
发文量
206
审稿时长
49 days
期刊介绍: Developmental and Comparative Immunology (DCI) is an international journal that publishes articles describing original research in all areas of immunology, including comparative aspects of immunity and the evolution and development of the immune system. Manuscripts describing studies of immune systems in both vertebrates and invertebrates are welcome. All levels of immunological investigations are appropriate: organismal, cellular, biochemical and molecular genetics, extending to such fields as aging of the immune system, interaction between the immune and neuroendocrine system and intestinal immunity.
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