脂质累积产物(LAP)指数对脊柱骨矿物质密度的饱和效应:基于人群的研究。

IF 3.3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Calcified Tissue International Pub Date : 2024-11-01 Epub Date: 2024-09-05 DOI:10.1007/s00223-024-01278-1
Ting Sun, Xin Tie, Lu Liu, Hongdie Liu, Li Tian
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引用次数: 0

摘要

脂质累积产物(LAP)对脊柱骨密度(BMD)有积极影响。然而,一旦 LAP 水平超过 27.26,脊柱骨密度的增加速度就会减慢甚至下降。这表明脂质代谢与 BMD 之间存在双相关系,即在一定范围内可能产生益处,而超过该范围则可能产生不利影响。本研究旨在调查美国成年人 LAP 指数与 BMD 之间的潜在关系,并探讨这种关系中是否存在潜在的饱和效应。本研究分析了美国国家健康与营养调查(NHANES)从 2007 年到 2018 年的数据。研究采用多元逐步回归模型来检验 LAP 指数与总脊柱 BMD 之间的关系。此外,还采用了广义加法模型和平滑曲线拟合算法来研究两者之间的关系,并进行了饱和效应研究以确定饱和水平。研究中使用的 LAP 计算公式为:(LAP =(腰围(WC)(厘米)- 58)女性的 LAP = (WC (cm) - 65) × TG (mmol/L)×甘油三酯(毫摩尔/升))。该研究共涉及 7913 名 20 岁或以上的参与者。通过多元逐步回归分析发现,LAP 分数越高的人脊柱总骨密度越高。在粗略模型和部分调整模型中,与 LAP 分值最低的四分位数(Q1)相比,LAP 分值最高的四分位数(Q4)的总脊柱 BMD 明显更高(P<0.05)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Saturation Effect of Lipid Accumulation Product (LAP) Index on Spinal Bone Mineral Density: A Population-Based Study.

Saturation Effect of Lipid Accumulation Product (LAP) Index on Spinal Bone Mineral Density: A Population-Based Study.

Lipid accumulation product (LAP) has a positive effect on spinal bone mineral density (BMD). However, once LAP levels exceed 27.26, the rate of spinal BMD increase slow down or even decline. This indicates a biphasic relationship between lipid metabolism and BMD, suggesting potential benefits within a certain range and possible adverse effects beyond that range. This study aimed to investigate the potential association between LAP index and BMD in US adults, as well as to explore the presence of a potential saturation effect in this relationship. This study analyzed data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2018. A multiple stepwise regression model was employed to examine the association between LAP index and total spinal BMD. Additionally, a generalized additive model and a smooth curve fitting algorithm were utilized to examine the relationship, and saturation effect study was conducted to determine the saturation level. The calculation formula of LAP used in the study was: (LAP = (waist circumstances (WC) (cm) - 58) × triglyceride (TG) (mmol/L)) for women, and (LAP = (WC (cm) - 65) × TG (mmol/L)) for men. The study involved a total of 7913 participants aged 20 years or older. Through multiple stepwise regression analysis, it was found that individuals with higher LAP scores exhibited higher total spinal BMD. In both the crude and partially adjusted models, total spinal BMD was significantly higher in the highest LAP quartile (Q4) compared to the lowest LAP quartile (Q1) (P < 0.05). Utilizing a generalized additive model and smooth curve, a nonlinear relationship between LAP and total spinal BMD was observed. Furthermore, the study identified the saturation value of LAP to be 27.26, indicating a saturation effect. This research highlights a nonlinear relationship between LAP and total spinal BMD, along with the presence of a saturation effect.

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来源期刊
Calcified Tissue International
Calcified Tissue International 医学-内分泌学与代谢
CiteScore
8.00
自引率
2.40%
发文量
112
审稿时长
4-8 weeks
期刊介绍: Calcified Tissue International and Musculoskeletal Research publishes original research and reviews concerning the structure and function of bone, and other musculoskeletal tissues in living organisms and clinical studies of musculoskeletal disease. It includes studies of cell biology, molecular biology, intracellular signalling, and physiology, as well as research into the hormones, cytokines and other mediators that influence the musculoskeletal system. The journal also publishes clinical studies of relevance to bone disease, mineral metabolism, muscle function, and musculoskeletal interactions.
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