小儿MN1::BEND2融合脑肿瘤缺乏经典星形母细胞瘤特征。

IF 5.8 2区医学 Q1 CLINICAL NEUROLOGY

Brain Pathology Pub Date : 2024-09-05 DOI:10.1111/bpa.13297

Nicholas Chapman, Mohammed Iqbal, Adam D Walker, Debra Hawes, Tom Belle Davidson, Nathan Robison, Benita Tamrazi, Jianling Ji, Mark D Krieger, Jennifer A Cotter

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引用次数: 0

摘要

儿科患者中三种不同的 MN1::BEND2 融合阳性肿瘤。(A）每位患者的临床病程各不相同，部分原因是初始诊断不同。每位患者均对全切除术反应良好，最近一次随访时病情稳定。(B）组织学上的多样性、典型星形母细胞瘤特征的缺乏以及关键标志物免疫表达的不同使得显微诊断具有挑战性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Lack of classical astroblastoma features in pediatric MN1::BEND2-fused brain tumors.

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Lack of classical astroblastoma features in pediatric MN1::BEND2-fused brain tumors.

Three distinct MN1::BEND2 fusion-positive tumors in pediatric patients. (A) Clinical course for each patient was variable in part due to differences in initial diagnosis. Each patient responded favorably to gross total resection and is stable at last follow-up. (B) Histologic diversity, lack of prominent classical astroblastoma features, and variable immunoexpression of key markers makes microscopic diagnosis challenging.

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来源期刊

Brain Pathology 医学-病理学

CiteScore

13.20

自引率

3.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Brain Pathology is the journal of choice for biomedical scientists investigating diseases of the nervous system. The official journal of the International Society of Neuropathology, Brain Pathology is a peer-reviewed quarterly publication that includes original research, review articles and symposia focuses on the pathogenesis of neurological disease.