回溯儿童白血病的诞生：一场加法之战

IF 5.1 2区医学 Q1 HEMATOLOGY

British Journal of Haematology Pub Date : 2024-09-05 DOI:10.1111/bjh.19747

Logan G Spector, Adam J de Smith

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引用次数: 0

摘要

儿童白血病的驱动基因突变非常多，每种突变都必须 "回溯 "到出生时采集的样本，以确定亚型的产前起源。目前，Bardini 等人首次成功回溯了 NUTM1 基因重排，揭示了这一特殊变异的生物学特性。为了全面了解这些疾病的产前起源，有必要继续回溯 NUTM1 基因重排和所有白血病典型体细胞改变。评论Bardini等：婴儿B细胞前体急性淋巴细胞白血病NUTM1基因重排的产前起源。Br J Haematol 2024（在线提前打印）。doi: 10.1111/bjh.19685。

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Backtracking childhood leukaemia to birth: A battle of addition.

Paediatric leukaemia has a long tail of driver mutations each of which must be 'backtracked' to samples taken at birth to identify the prenatal origin of a subtype. Presently, Bardini et al. describe the first successful backtracking of an NUTM1 rearrangement, which sheds light on the biology of this particular alteration. Continued backtracking of NUTM1 rearrangements, and all leukaemia-typical somatic alterations, is necessary to fully understand the prenatal origin of these diseases. Commentary on: Bardini et al. Prenatal origin of NUTM1 gene rearrangement in infant B-cell precursor acute lymphoblastic leukaemia. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19685.

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来源期刊

British Journal of Haematology 医学-血液学

CiteScore

8.60

自引率

4.60%

发文量

565

审稿时长

1 months

期刊介绍： The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.