通过可见光介导的炔烃二官能化反应制备二氟甲基化苯并噻吩。

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

The Journal of Organic Chemistry Pub Date : 2024-09-20 Epub Date: 2024-09-06 DOI:10.1021/acs.joc.4c01528

Dong Zhang, Yu Sun, Ganwen Wang, Ying Liu, Chunjie Ni, Qingzhi Ji, Xiaojuan Xu, Zheng Fang

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引用次数: 0

摘要

本研究开发了一种通过可见光介导的炔烃二官能化制备二氟甲基化苯并噻吩的高效方法。该方法以廉价的二氟甲烷亚硫酸钠（HCF2SO2Na）为氟源，在温和的反应条件下获得了多种苯并噻吩衍生物，收率从中等到极佳。此外，该反应操作简单，易于推广。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Preparation of Difluoromethylated Benzothiophene by Visible-Light-Mediated Alkyne Difunctionalization Reaction.

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Preparation of Difluoromethylated Benzothiophene by Visible-Light-Mediated Alkyne Difunctionalization Reaction.

An efficient method for the preparation of difluoromethylated benzothiophenes via visible-light-mediated alkyne difunctionalization was developed. In this method, inexpensive sodium difluoromethanesulfinate (HCF₂SO₂Na) was used as the fluorine source, and a variety of benzothiophene derivatives were obtained in moderate to excellent yield under mild reaction conditions. Moreover, the reaction operation is simple and easy to scale up.

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来源期刊

The Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.