介导异体免疫细胞疗法的单向街道识别方法

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2024-09-05 DOI:10.1016/j.stem.2024.07.005

Fuguo Liu, Rizwan Romee

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引用次数: 0

摘要

CD54 和 CD58 是介导免疫突触有效形成的粘附蛋白。Hammer 等人的研究表明，在 T 细胞和 NK 细胞中消减这些分子可防止其免疫排斥反应，同时保持其效应功能。这些发现将大大有助于推进我们生产 "现成的 "异体产品的工作。

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A one-way street recognition approach to mediate allogeneic immune cell therapies

CD54 and CD58 are adhesion proteins that mediate efficient immune synapse formation. Hammer et al. now show that the abrogation of these molecules in T and NK cells prevents their immune rejection while maintaining their effector function. These findings should significantly help advance our efforts to generate “off-the-shelf” allogeneic products.

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.