HerA 亚家族蛋白质的结构、功能和进化

IF 3 3区生物学 Q2 GENETICS & HEREDITY

DNA Repair Pub Date : 2024-09-02 DOI:10.1016/j.dnarep.2024.103760

Yiyang Sun , Kaiying Cheng

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引用次数: 0

摘要

HerA 是一种 ATP 依赖性转运酶，广泛分布于古生菌和一些细菌中。它属于HerA/FtsK转运酶细菌家族，是RecA家族的一个分支。目前已发现，HerA 参与 DNA 双链断裂（DSB）的修复，或通过将其他蛋白质组装成大型复合物来赋予抗噬菌体防御能力。近年来，人们对古细菌和细菌中 HerA 亚家族成员的生物信息学、生物化学、结构和功能有了越来越多的了解。这篇综述比较了不同 HerA 在结构上的差异，并阐明了它们各自在特定生命过程中的作用。

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Structure, function and evolution of the HerA subfamily proteins

HerA is an ATP-dependent translocase that is widely distributed in archaea and some bacteria. It belongs to the HerA/FtsK translocase bacterial family, which is a subdivision of the RecA family. Currently, it is identified that HerA participates in the repair of DNA double-strand breaks (DSBs) or confers anti-phage defense by assembling other proteins into large complexes. In recent years, there has been a growing understanding of the bioinformatics, biochemistry, structure, and function of HerA subfamily members in both archaea and bacteria. This comprehensive review compares the structural disparities among diverse HerAs and elucidates their respective roles in specific life processes.

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来源期刊

DNA Repair 生物-毒理学

CiteScore

7.60

自引率

5.30%

发文量

审稿时长

59 days

期刊介绍： DNA Repair provides a forum for the comprehensive coverage of DNA repair and cellular responses to DNA damage. The journal publishes original observations on genetic, cellular, biochemical, structural and molecular aspects of DNA repair, mutagenesis, cell cycle regulation, apoptosis and other biological responses in cells exposed to genomic insult, as well as their relationship to human disease. DNA Repair publishes full-length research articles, brief reports on research, and reviews. The journal welcomes articles describing databases, methods and new technologies supporting research on DNA repair and responses to DNA damage. Letters to the Editor, hot topics and classics in DNA repair, historical reflections, book reviews and meeting reports also will be considered for publication.