Yudai Xu, Zijian Wang, Shumin Li, Jun Su, Lijuan Gao, Junwen Ou, Zhanyi Lin, Oscar Junhong Luo, Chanchan Xiao, Guobing Chen
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引用次数: 0
摘要
T 细胞在维持人体整体健康方面发挥着不可替代的重要作用。然而，随着年龄的增长，它们的功能也会发生变化。了解 T 细胞衰老的具体特征至关重要，因为这些知识对于深入了解衰老相关疾病的发病机理和开发有效的治疗策略至关重要。在这篇综述中，我们全面考察了现有的关于免疫器官衰老特征的研究。此外，我们还阐明了 T 细胞在衰老过程中发生的变化和潜在机制。此外，我们还讨论了有关 T 细胞衰老相关疾病的最新研究进展。这些发现为在衰老背景下研究 T 细胞提供了一个全新的视角。
An in-depth understanding of the role and mechanisms of T cells in immune organ aging and age-related diseases.
T cells play a critical and irreplaceable role in maintaining overall health. However, their functions undergo alterations as individuals age. It is of utmost importance to comprehend the specific characteristics of T-cell aging, as this knowledge is crucial for gaining deeper insights into the pathogenesis of aging-related diseases and developing effective therapeutic strategies. In this review, we have thoroughly examined the existing studies on the characteristics of immune organ aging. Furthermore, we elucidated the changes and potential mechanisms that occur in T cells during the aging process. Additionally, we have discussed the latest research advancements pertaining to T-cell aging-related diseases. These findings provide a fresh perspective for the study of T cells in the context of aging.
期刊介绍：
Science China Life Sciences is a scholarly journal co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China, and it is published by Science China Press. The journal is dedicated to publishing high-quality, original research findings in both basic and applied life science research.
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