对接受性别平权激素治疗的变性人进行免疫学研究。

IF 67.7 1区医学 Q1 IMMUNOLOGY

Nature Reviews Immunology Pub Date : 2024-09-04 DOI:10.1038/s41577-024-01070-0

Anna James, Petter Brodin

{"title":"对接受性别平权激素治疗的变性人进行免疫学研究。","authors":"Anna James, Petter Brodin","doi":"10.1038/s41577-024-01070-0","DOIUrl":null,"url":null,"abstract":"Personalized medicine for all requires a shift in science and clinical culture that puts more emphasis on the sources of inter-individual variation. Important examples are sex differences in the presentation and severity of diseases, as well as in responses to therapy. Understanding the mechanisms that drive these differences is important in the context of individualized healthcare, and also to better understand the immune sequelae of long-term sex hormone supplementation or inhibition in transgender individuals. Sex-specific differences in immunity are determined by genetics and by hormones. This Comment discusses first insights into the consequences of long-term sex-hormone supplementation on immunity in transgender individuals.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":null,"pages":null},"PeriodicalIF":67.7000,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Immunological studies in trans-individuals undergoing gender affirming hormone therapy\",\"authors\":\"Anna James, Petter Brodin\",\"doi\":\"10.1038/s41577-024-01070-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Personalized medicine for all requires a shift in science and clinical culture that puts more emphasis on the sources of inter-individual variation. Important examples are sex differences in the presentation and severity of diseases, as well as in responses to therapy. Understanding the mechanisms that drive these differences is important in the context of individualized healthcare, and also to better understand the immune sequelae of long-term sex hormone supplementation or inhibition in transgender individuals. Sex-specific differences in immunity are determined by genetics and by hormones. This Comment discusses first insights into the consequences of long-term sex-hormone supplementation on immunity in transgender individuals.\",\"PeriodicalId\":19049,\"journal\":{\"name\":\"Nature Reviews Immunology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":67.7000,\"publicationDate\":\"2024-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Reviews Immunology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.nature.com/articles/s41577-024-01070-0\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Immunology","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41577-024-01070-0","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

要实现人人享有个性化医疗，就必须转变科学和临床文化，更加重视个体间差异的来源。重要的例子包括疾病表现和严重程度的性别差异，以及对治疗的反应。在个体化医疗保健的背景下，了解这些差异的驱动机制非常重要，这也有助于更好地理解变性人长期补充或抑制性激素所产生的免疫后遗症。免疫力的性别差异由遗传和激素决定。本评论探讨了变性人长期补充性激素对免疫力影响的初步认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Immunological studies in trans-individuals undergoing gender affirming hormone therapy

查看原文本刊更多论文

Immunological studies in trans-individuals undergoing gender affirming hormone therapy

Personalized medicine for all requires a shift in science and clinical culture that puts more emphasis on the sources of inter-individual variation. Important examples are sex differences in the presentation and severity of diseases, as well as in responses to therapy. Understanding the mechanisms that drive these differences is important in the context of individualized healthcare, and also to better understand the immune sequelae of long-term sex hormone supplementation or inhibition in transgender individuals. Sex-specific differences in immunity are determined by genetics and by hormones. This Comment discusses first insights into the consequences of long-term sex-hormone supplementation on immunity in transgender individuals.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nature Reviews Immunology 医学-免疫学

CiteScore

93.40

自引率

0.40%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.