Mervat A AbdRabou, Ahmed B M Mehany, Diaa Massoud, Ahmed Nabeeh, Aml M Asran, Mousa O Germoush, Aljohara M Al-Otaibi, Ahmed Atwa
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GD + MSCs group (pregnant rats treated with MSCs). GD + OLE + MSCs group (pregnant rats were treated with both MSCs and OLE).</p><p><strong>Results: </strong>STZ induced significant changes in liver parameters, lipid profile, and oxidative stress. Treatment with OLE, BM-MSCs, and their combination significantly ameliorated STZ-induced liver damage and oxidative stress. STZ resulted in a significant change in liver parameters, lipid profile, and oxidative stress. OLE, BM-MSC, and combination have significantly improved STZ-induced deterioration in liver and improved oxidative stress.</p><p><strong>Conclusions: </strong>The findings demonstrate that OLE and BM-MSCs have beneficial effects in mitigating diabetes-related liver alterations. These outcomes showed that OLE and BM-MSC have beneficial effects in alleviating diabetes-related alterations in the liver.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mitigation of biochemical alterations in streptozotocin-induced gestational diabetes in rats through mesenchymal stem cells and olive leaf extract.\",\"authors\":\"Mervat A AbdRabou, Ahmed B M Mehany, Diaa Massoud, Ahmed Nabeeh, Aml M Asran, Mousa O Germoush, Aljohara M Al-Otaibi, Ahmed Atwa\",\"doi\":\"10.1002/jez.2862\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Treatment with mesenchymal stem cells (MSCs) is a new promising therapeutic approach with substantial very auspicious potential. 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引用次数: 0
摘要
使用间充质干细胞（MSCs）治疗是一种新的治疗方法，具有巨大的潜力。研究表明，间充质干细胞能保护各种器官免受损伤。本研究旨在评估橄榄叶提取物（OLE）、骨髓间充质干细胞（BM-MSCs）及其组合治疗对糖尿病妊娠大鼠肝毒性的影响：将动物分为以下五组（每组 10 只妊娠大鼠）：对照组、GDM 组和 OLE 组（大鼠接受的链脲佐菌素（STZ）剂量为 35 毫克/千克体重）。GD + OLE 组（怀孕大鼠按每公斤体重 200 毫克提取物的剂量服用 OLE）。GD + 间充质干细胞组（怀孕大鼠接受间充质干细胞治疗）。GD + OLE + 间充质干细胞组（怀孕大鼠同时接受间充质干细胞和 OLE 治疗）：结果：STZ引起肝脏参数、血脂和氧化应激的显著变化。使用 OLE、BM-间充质干细胞及其组合治疗可显著改善 STZ 诱导的肝损伤和氧化应激。STZ导致肝脏参数、血脂谱和氧化应激发生明显变化。OLE、BM-间充质干细胞及其组合能明显改善STZ诱导的肝脏恶化，并改善氧化应激：结论：研究结果表明，OLE 和 BM-MSCs 有助于缓解糖尿病相关肝脏改变。这些结果表明，OLE和BM-间充质干细胞对缓解与糖尿病相关的肝脏改变有益。
Mitigation of biochemical alterations in streptozotocin-induced gestational diabetes in rats through mesenchymal stem cells and olive leaf extract.
Treatment with mesenchymal stem cells (MSCs) is a new promising therapeutic approach with substantial very auspicious potential. They have been shown to protect various played a role in protecting organs from damage. This current study aims to evaluate the impact of the treatment of olive leaf extract (OLE), bone marrow-derived (BM-MSCs), and their combination on hepatotoxicity in pregnant rats with diabetes.
Methods: Animals were divided into five groups (10 pregnant rats each) as follows: control, GDM group, and OLE group (rats received streptozotocin (STZ) at a dose of 35 mg/kg body weight). GD + OLE set (pregnant rats were administered OLE at a dose of 200 mg extract/kg of body weight). GD + MSCs group (pregnant rats treated with MSCs). GD + OLE + MSCs group (pregnant rats were treated with both MSCs and OLE).
Results: STZ induced significant changes in liver parameters, lipid profile, and oxidative stress. Treatment with OLE, BM-MSCs, and their combination significantly ameliorated STZ-induced liver damage and oxidative stress. STZ resulted in a significant change in liver parameters, lipid profile, and oxidative stress. OLE, BM-MSC, and combination have significantly improved STZ-induced deterioration in liver and improved oxidative stress.
Conclusions: The findings demonstrate that OLE and BM-MSCs have beneficial effects in mitigating diabetes-related liver alterations. These outcomes showed that OLE and BM-MSC have beneficial effects in alleviating diabetes-related alterations in the liver.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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