非高密度脂蛋白胆固醇、症状性颅内动脉狭窄与轻微中风的复发性血管风险。

IF 3 2区 医学 Q2 PERIPHERAL VASCULAR DISEASE
Haimei Fan, Tingting Liu, Kaili Zhang, Yongle Wang, Rong Wang, Fei Yang, Feifei Chen, Yanli Zhang, Huaai Guo, Xinyi Li, Xuemei Wu, Xiaoyuan Niu
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引用次数: 0

摘要

目的:我们旨在评估非高密度脂蛋白胆固醇(non-HDL-C)与无症状性颅内动脉狭窄(sICAS)之间的关系,以及非高密度脂蛋白胆固醇对轻度缺血性卒中患者(NIHSS评分≤5分)复发性血管事件的影响:这项前瞻性研究基于脑卒中发生后 72 小时内就诊患者的数据。我们纳入了 2019 年 9 月至 2021 年 11 月期间 8 家中国医院收治的患者。采用多变量回归模型和限制性立方样条分析评估了非高密度脂蛋白胆固醇与sICAS和复发性血管风险的关系:结果:在分析的 2544 名患者中,有 652 人(25.6%)在 12 个月后被确诊为 sICAS。非高密度脂蛋白胆固醇升高与sICAS的高发病率有关,五分位变量和连续变量的调整奇异比分别为1.36([95% CI, 1.01-1.81])和1.14([95% CI, 1.04-1.24))。与第一五分位数的患者相比,非高密度脂蛋白胆固醇第五五分位数的患者复发缺血性卒中的调整后危险比为 1.19([95% CI 0.78-1.80]),颅内出血的调整后危险比为 0.39([95% CI, 0.17-0.91]):结论:非 HDL-C 水平可能是预测 sICAS 的有效指标。结论:非 HDL-C 水平可能是预测 sICAS 的有用指标,非 HDL-C 水平越高,轻度非心源性卒中发生颅内出血的风险越低,但发生复发性缺血性卒中的风险并不高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Non-HDL-C, Symptomatic Intracranial Arterial Stenosis, and Recurrent Vascular Risk in Minor Stroke.

Aim: We aimed to assess the association between non-high-density lipoprotein cholesterol (non-HDL-C) and symptomatic intracranial artery stenosis (sICAS), as well as the impact of non-HDL-C on recurrent vascular events in patients with mild ischemic stroke ( NIHSS score ≤ 5).

Methods: This prospective study was based on data from patients presenting within 72 hours of stroke occurrence. We included patients admitted to 8 Chinese hospitals between September 2019 and November 2021. The associations of non-HDL-C with sICAS and recurrent vascular risk were assessed using multivariate regression models and a restricted cubic spline analysis.

Results: Among the 2,544 patients analyzed at 12 months, 652 (25.6%) were diagnosed with sICAS. Elevated non-HDL-C was linked to a higher incidence of sICAS, and the adjusted odd ratios for quintile variables and continuous variables were 1.36 ([95% CI, 1.01-1.81]) and 1.14 ([95% CI, 1.04-1.24). In comparison to those in the first quintile, the adjusted hazard ratio of the fifth quintile of non-HDL-C was 1.19 ([95% CI 0.78-1.80]) for recurrent ischemic stroke and was 0.39 ([95% CI, 0.17-0.91]) for intracranialhemorrhage.

Conclusions: The non-HDL-C level may be a useful predictor of sICAS. Higher non-HDL-C levels may be associated with a lower risk of intracranial hemorrhage in mild, noncardiogenic stroke, but not a higher risk of recurrent ischemic stroke.

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来源期刊
CiteScore
6.60
自引率
15.90%
发文量
271
审稿时长
1 months
期刊介绍: JAT publishes articles focused on all aspects of research on atherosclerosis, vascular biology, thrombosis, lipid and metabolism.
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