评估 N 端前 B 型钠尿肽作为急性磷化铝中毒死亡率预测生物标志物的作用。

IF 2 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biomarkers Pub Date : 2024-09-13 DOI:10.1080/1354750X.2024.2400910

Emad Ahmed Elsayed, Sarah Atef Eweda, Sarah Ahmad El-Morsy

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引用次数: 0

摘要

背景在埃及，磷化铝（ALP）因其心脏毒性是一种已知的致命毒药。本研究旨在评估 N 端前 B 型钠尿肽（NT-proBNP）对 ALP 中毒患者死亡率的预测能力。研究方法这项前瞻性研究的对象是 2022 年 7 月至 12 月期间在艾因夏姆斯大学医院中毒控制中心住院的 ALP 中毒患者。入院后，对所有患者进行随访，并分析其 NT-proBNP、肌钙蛋白 I（cTnI）和肌酸激酶心肌带（CK-MB）的水平。结果研究共纳入 30 名患者，分为存活者和非存活者。与初始 cTnI 和 CK-MB 水平相比，非存活者的初始 NT-proBNP 水平明显更高。研究发现，NT-proBNP 预测死亡率的最佳临界点为≥72 pg/ml，AUC 为 0.869。结论：可以得出结论，NT-proBNP 可以作为 ALP 中毒死亡率的早期预测指标。

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Assessment of the role of N-terminal pro-B-type natriuretic peptide as a predictive biomarker of mortality in acute aluminum phosphide poisoning.

Background: In Egypt, aluminum phosphide (ALP) is a known lethal poison due to its cardiotoxicity. This study aimed to evaluate the predictive ability of N-terminal pro-B-type natriuretic peptide (NT-proBNP) for mortality in ALP-poisoned patients.

Methods: This prospective study was conducted on patients with ALP poisoning admitted to the Poison Control Center Ain Shams University Hospitals between July and December 2022. Upon admission, all patients were followed up and had their levels of NT-proBNP, troponin I (cTnI), and creatine kinase myocardial band (CK-MB) analyzed.

Results: Thirty patients were enrolled in the study and were divided into survivors and non-survivors. The initial NT-proBNP levels were significantly higher among non-survivors in contrast to the initial cTnI and CK-MB levels. The study identified that the best cutoff point of NT-proBNP for predicting mortality was ≥72 pg/ml, with AUC (0.869).

Conclusion: It can be concluded that NT-proBNP can serve as an early predictor of mortality in ALP poisoning.

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来源期刊

Biomarkers 医学-毒理学

CiteScore

5.00

自引率

3.80%

发文量

140

审稿时长

3 months

期刊介绍： The journal Biomarkers brings together all aspects of the rapidly growing field of biomarker research, encompassing their various uses and applications in one essential source. Biomarkers provides a vital forum for the exchange of ideas and concepts in all areas of biomarker research. High quality papers in four main areas are accepted and manuscripts describing novel biomarkers and their subsequent validation are especially encouraged: • Biomarkers of disease • Biomarkers of exposure • Biomarkers of response • Biomarkers of susceptibility Manuscripts can describe biomarkers measured in humans or other animals in vivo or in vitro. Biomarkers will consider publishing negative data from studies of biomarkers of susceptibility in human populations.