用于治疗神经退行性疾病的神经营养素肽模拟物。

IF 6.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2024-09-02 DOI:10.1016/j.drudis.2024.104156

Dev Madhubala , Rosy Mahato , Mojibur R. Khan , Asis Bala , Ashis K. Mukherjee

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引用次数: 0

摘要

神经生长因子和脑源性神经营养因子等神经营养素对神经元的存活起着至关重要的作用。然而，结合更好的特性可以提高它们在神经退行性疾病（NDs）中的疗效。模仿这些神经营养素的拟肽类药物显示出治疗 NDs 的潜力。本研究强调了利用神经营养素拟肽物治疗 NDs 及其益处。通过提高生物利用度和稳定性，这些分子可以彻底改变 NDs 的治疗方法。这篇深度综述为研究人员和药品开发人员提供了指导，让他们深入了解不断变化的神经退行性医学领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Neurotrophin peptidomimetics for the treatment of neurodegenerative diseases

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Neurotrophin peptidomimetics for the treatment of neurodegenerative diseases

Neurotrophins, such as nerve growth factor and brain-derived neurotrophic factor, play an essential role in the survival of neurons. However, incorporating better features can increase their therapeutic efficacy in neurodegenerative diseases (NDs). Peptidomimetics, which mimic these neurotrophins, show potential for treating NDs. This study emphasizes the use of peptidomimetics from neurotrophins for treating NDs and their benefits. By improving bioavailability and stability, these molecules can completely transform the therapy for NDs. This in-depth review guides researchers and pharmaceutical developers, providing insight into the changing field of neurodegenerative medicine.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.