Aleksandr B Shek, Rano B Alieva, Alisher A Abdullaev, Khurshid G Fozilov, Shavkat U Khoshimov, Guzal J Abdullaeva, Darya V Zakirova, Rano A Kurbanova, Lilya E Kan, Andrey R Kim
{"title":"利用基因升高的脂蛋白(a)水平预测女性冠心病 5 年主要不良心血管事件的优势。","authors":"Aleksandr B Shek, Rano B Alieva, Alisher A Abdullaev, Khurshid G Fozilov, Shavkat U Khoshimov, Guzal J Abdullaeva, Darya V Zakirova, Rano A Kurbanova, Lilya E Kan, Andrey R Kim","doi":"10.31083/j.rcm2508308","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate major adverse cardiovascular events (MACE) in patients with coronary artery disease (CAD) over 5 years, in general, and depending on sex, lipoprotein(a) level, and number of kringle IV type 2 (KIV-2) repeats in the Lipoprotein(A) (<i>LPA</i>) gene.</p><p><strong>Methods: </strong>This study comprised 216 patients (120 women and 96 men) hospitalized with a diagnosis of \"CAD, unstable angina IIB class\". The three-point risk of MACEs was assessed over 5 years: cardiovascular death, non-fatal myocardial infarction, and stroke. The number of KIV-2 repeats in the <i>LPA</i> gene was determined by quantitative real-time polymerase chain reaction (qPCR).</p><p><strong>Results: </strong>The relative risk of MACE in patients with elevated lipoprotein(a) (Lp(a)) was 2.0 (95% CI 1.04-3.87, <i>p</i> <math><mo><</mo></math> 0.05) for quartile 4 (Q4) <math><mo>≥</mo></math> 48 mg/dL versus quartile 1 (Q1) <math><mo>≤</mo></math> 6 mg/dL. This was mainly attributable to an increase in men-relative risk (RR) 2.6 (95% CI 1.10-6.16, <i>p</i> <math><mo><</mo></math> 0.05)-but not in women: RR 1.4 (95% CI 0.50-3.92). Mean lipoprotein(a) levels were inversely correlated with 42.5 and 7.5 for Q1 and Q4 KIV-2 repeat numbers, respectively. The relative risks of MACE for Q1 vs. Q4 KIV-2 repeats were as follows: 3.0 (95% CI 1.48-6.08, <i>p</i> <math><mo><</mo></math> 0.001) for all patients; 3.0 (95% CI 1.20-6.55, <i>p</i> <math><mo><</mo></math> 0.01) for men; 3.3 (95% CI 1.02-10.4, <i>p</i> <math><mo><</mo></math> 0.05) for women.</p><p><strong>Conclusions: </strong>Quantifying kringle IV type 2 repeat copy number in the <i>LPA</i> gene using qPCR more accurately reflects the risk of major adverse cardiovascular events within 5 years in women with coronary artery disease.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11366988/pdf/","citationCount":"0","resultStr":"{\"title\":\"Advantages of using Genetically Elevated Lipoprotein(a) Levels in Predicting 5-Year Major Adverse Cardiovascular Events Relating to Coronary Artery Disease in Women.\",\"authors\":\"Aleksandr B Shek, Rano B Alieva, Alisher A Abdullaev, Khurshid G Fozilov, Shavkat U Khoshimov, Guzal J Abdullaeva, Darya V Zakirova, Rano A Kurbanova, Lilya E Kan, Andrey R Kim\",\"doi\":\"10.31083/j.rcm2508308\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>This study aimed to investigate major adverse cardiovascular events (MACE) in patients with coronary artery disease (CAD) over 5 years, in general, and depending on sex, lipoprotein(a) level, and number of kringle IV type 2 (KIV-2) repeats in the Lipoprotein(A) (<i>LPA</i>) gene.</p><p><strong>Methods: </strong>This study comprised 216 patients (120 women and 96 men) hospitalized with a diagnosis of \\\"CAD, unstable angina IIB class\\\". The three-point risk of MACEs was assessed over 5 years: cardiovascular death, non-fatal myocardial infarction, and stroke. The number of KIV-2 repeats in the <i>LPA</i> gene was determined by quantitative real-time polymerase chain reaction (qPCR).</p><p><strong>Results: </strong>The relative risk of MACE in patients with elevated lipoprotein(a) (Lp(a)) was 2.0 (95% CI 1.04-3.87, <i>p</i> <math><mo><</mo></math> 0.05) for quartile 4 (Q4) <math><mo>≥</mo></math> 48 mg/dL versus quartile 1 (Q1) <math><mo>≤</mo></math> 6 mg/dL. This was mainly attributable to an increase in men-relative risk (RR) 2.6 (95% CI 1.10-6.16, <i>p</i> <math><mo><</mo></math> 0.05)-but not in women: RR 1.4 (95% CI 0.50-3.92). Mean lipoprotein(a) levels were inversely correlated with 42.5 and 7.5 for Q1 and Q4 KIV-2 repeat numbers, respectively. The relative risks of MACE for Q1 vs. Q4 KIV-2 repeats were as follows: 3.0 (95% CI 1.48-6.08, <i>p</i> <math><mo><</mo></math> 0.001) for all patients; 3.0 (95% CI 1.20-6.55, <i>p</i> <math><mo><</mo></math> 0.01) for men; 3.3 (95% CI 1.02-10.4, <i>p</i> <math><mo><</mo></math> 0.05) for women.</p><p><strong>Conclusions: </strong>Quantifying kringle IV type 2 repeat copy number in the <i>LPA</i> gene using qPCR more accurately reflects the risk of major adverse cardiovascular events within 5 years in women with coronary artery disease.</p>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2024-08-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11366988/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.31083/j.rcm2508308\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/8/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.31083/j.rcm2508308","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
摘要
研究背景本研究旨在调查冠状动脉疾病(CAD)患者在5年内发生的主要心血管不良事件(MACE)的总体情况,以及与性别、脂蛋白(A)水平和脂蛋白(A)(LPA)基因中克林格IV型2(KIV-2)重复序列数量有关的情况:这项研究包括216名被诊断为 "CAD,不稳定型心绞痛 IIB 级 "的住院患者(120 名女性和 96 名男性)。评估了5年内MACE的三点风险:心血管死亡、非致死性心肌梗死和中风。通过实时定量聚合酶链反应(qPCR)测定了LPA基因中KIV-2重复序列的数量:结果:脂蛋白(a)(Lp(a))升高的四分位数 4(Q4)≥ 48 mg/dL 与四分位数 1(Q1)≤ 6 mg/dL 相比,MACE 的相对风险为 2.0(95% CI 1.04-3.87,P 0.05)。这主要归因于男性相对风险 (RR) 2.6 (95% CI 1.10-6.16, p 0.05)的增加,而女性则没有:RR 1.4 (95% CI 0.50-3.92)。平均脂蛋白(a)水平分别与 Q1 和 Q4 KIV-2 重复次数的 42.5 和 7.5 成反比。Q1 与 Q4 KIV-2 重复序列发生 MACE 的相对风险如下:所有患者的相对风险为3.0(95% CI 1.48-6.08,P 0.001);男性为3.0(95% CI 1.20-6.55,P 0.01);女性为3.3(95% CI 1.02-10.4,P 0.05):结论:使用 qPCR 对 LPA 基因中的 kringle IV 2 型重复拷贝数进行量化能更准确地反映冠心病女性患者 5 年内发生重大不良心血管事件的风险。
Advantages of using Genetically Elevated Lipoprotein(a) Levels in Predicting 5-Year Major Adverse Cardiovascular Events Relating to Coronary Artery Disease in Women.
Background: This study aimed to investigate major adverse cardiovascular events (MACE) in patients with coronary artery disease (CAD) over 5 years, in general, and depending on sex, lipoprotein(a) level, and number of kringle IV type 2 (KIV-2) repeats in the Lipoprotein(A) (LPA) gene.
Methods: This study comprised 216 patients (120 women and 96 men) hospitalized with a diagnosis of "CAD, unstable angina IIB class". The three-point risk of MACEs was assessed over 5 years: cardiovascular death, non-fatal myocardial infarction, and stroke. The number of KIV-2 repeats in the LPA gene was determined by quantitative real-time polymerase chain reaction (qPCR).
Results: The relative risk of MACE in patients with elevated lipoprotein(a) (Lp(a)) was 2.0 (95% CI 1.04-3.87, p 0.05) for quartile 4 (Q4) 48 mg/dL versus quartile 1 (Q1) 6 mg/dL. This was mainly attributable to an increase in men-relative risk (RR) 2.6 (95% CI 1.10-6.16, p 0.05)-but not in women: RR 1.4 (95% CI 0.50-3.92). Mean lipoprotein(a) levels were inversely correlated with 42.5 and 7.5 for Q1 and Q4 KIV-2 repeat numbers, respectively. The relative risks of MACE for Q1 vs. Q4 KIV-2 repeats were as follows: 3.0 (95% CI 1.48-6.08, p 0.001) for all patients; 3.0 (95% CI 1.20-6.55, p 0.01) for men; 3.3 (95% CI 1.02-10.4, p 0.05) for women.
Conclusions: Quantifying kringle IV type 2 repeat copy number in the LPA gene using qPCR more accurately reflects the risk of major adverse cardiovascular events within 5 years in women with coronary artery disease.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.