患有胎儿酒精谱系障碍的中年人的皮层下体积。

IF 4.1 Q1 CLINICAL NEUROLOGY
Brain communications Pub Date : 2024-09-03 eCollection Date: 2024-01-01 DOI:10.1093/braincomms/fcae273
Amanda Bischoff-Grethe, Susan A Stoner, Edward P Riley, Eileen M Moore
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引用次数: 0

摘要

对有产前酒精暴露(PAE)的青少年和年轻成人进行的研究最一致的报告是胼胝体、小脑和皮层下结构的体积减小。然而,这种情况是否会持续到成年中期,或者随着年龄的增长,胎儿酒精中毒综合症患者的体积是否会过早下降,目前还不得而知。48名患有胎儿酒精谱系障碍(FASD)的患者和28名年龄在30至65岁之间的健康对比参与者参加了一次3T核磁共振成像会议,会议产生了可用的T1加权和T2加权结构图像。主要分析包括使用FreeSurfer软件测量尾状核、丘脑、苍白球、小脑和胼胝体的体积。分析同时检查了原始体积测量值和根据总体颅内体积(ICV)调整后的皮层下体积。模型测试了年龄、性别和组别的主效应,以及组别与年龄和组别与性别的交互作用。我们发现了组别的主效应;在使用原始体积的模型(P's < 0.001)和使用根据 ICV 调整后的体积的模型(P's < 0.046)中,FASD 参与者的所有区域都明显较小。虽然组别与年龄之间没有明显的交互作用,但与健康的对比女性和患有 FASD 的男性相比,患有 FASD 的女性的胼胝体体积较小(P's < 0.001)。与儿童和青少年一样,30 至 65 岁患有 FASD 的成人皮层下结构的体积相对于健康对比成人也有所减少,这表明 PAE 的影响持续存在。此外,在女性 FASD 患者中观察到的胼胝体体积缩小可能表明其退化速度更快,这可能会随着这些人年龄的增长而对其认知能力产生影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Subcortical volume in middle-aged adults with fetal alcohol spectrum disorders.

Studies of youth and young adults with prenatal alcohol exposure (PAE) have most consistently reported reduced volumes of the corpus callosum, cerebellum and subcortical structures. However, it is unknown whether this continues into middle adulthood or if individuals with PAE may experience premature volumetric decline with aging. Forty-eight individuals with fetal alcohol spectrum disorders (FASD) and 28 healthy comparison participants aged 30 to 65 participated in a 3T MRI session that resulted in usable T1-weighted and T2-weighted structural images. Primary analyses included volumetric measurements of the caudate, putamen, pallidum, cerebellum and corpus callosum using FreeSurfer software. Analyses were conducted examining both raw volumetric measurements and subcortical volumes adjusted for overall intracranial volume (ICV). Models tested for main effects of age, sex and group, as well as interactions of group with age and group with sex. We found the main effects for group; all regions were significantly smaller in participants with FASD for models using raw volumes (P's < 0.001) as well as for models using volumes adjusted for ICV (P's < 0.046). Although there were no significant interactions of group with age, females with FASD had smaller corpus callosum volumes relative to both healthy comparison females and males with FASD (P's < 0.001). As seen in children and adolescents, adults aged 30 to 65 with FASD showed reduced volumes of subcortical structures relative to healthy comparison adults, suggesting persistent impact of PAE. Moreover, the observed volumetric reduction of the corpus callosum in females with FASD could suggest more rapid degeneration, which may have implications for cognition as these individuals continue to age.

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CiteScore
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