CYP2C19 护理点检测的准确性和技术特点：系统综述。

IF 1.9 4区医学 Q3 PHARMACOLOGY & PHARMACY

Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2024-09-04 DOI:10.1080/14622416.2024.2392479

Eve Tomlinson, Chris Cooper, Hayley E Jones, Catalina Lopez Manzano, Rachel Palmer, Joe Carroll, Ayman Sadek, Nicky J Welton, Mariska Leeflang, Penny Whiting

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引用次数: 0

摘要

目的：评估CYP2C19护理点检测（POCT）的准确性和技术特征：系统回顾在任何人群或环境中对检测CYP2C19功能缺失（LOF）等位基因的POCT进行评估的主要研究：11项研究提供了准确性数据（8项为Spartan；1项为Genomadix Cube；1项为GMEX；1项为Genedrive）。这些 POCT 对其检测的等位基因具有非常高的灵敏度和特异性。22 项研究报告了技术特点：POCT 操作简便，结果提供迅速。有关检测失败率和成本的数据有限：结论：CYP2C19 POCT 可作为实验室检测的有效替代方法，指导抗血小板治疗。关于准确性（GMEX；Genedrive）、检测失败率和成本（所有 POCT），还需要进一步的数据。

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Accuracy and technical characteristics of CYP2C19 point of care tests: a systematic review.

Aim: To assess the accuracy and technical characteristics of CYP2C19 point of care tests (POCTs).Patients & methods: Systematic review of primary studies, in any population or setting, that evaluated POCTs for detecting CYP2C19 loss of function (LOF) alleles.Results: Eleven studies provided accuracy data (eight Spartan; one Genomadix Cube; one GMEX; one Genedrive). The POCTs had very high sensitivity and specificity for the alleles they tested for. Twenty-two studies reported technical characteristics: POCTs were easy to operate and provided results quickly. Limited data were reported for test failure rate and cost.Conclusion: CYP2C19 POCTs may be a useful alternative to laboratory-based testing to guide antiplatelet therapy. Further data are required on accuracy (GMEX; Genedrive), test failure and cost (all POCT).

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来源期刊

Pharmacogenomics 医学-药学

CiteScore

3.40

自引率

9.50%

发文量

审稿时长

4-8 weeks

期刊介绍： Pharmacogenomics (ISSN 1462-2416) is a peer-reviewed journal presenting reviews and reports by the researchers and decision-makers closely involved in this rapidly developing area. Key objectives are to provide the community with an essential resource for keeping abreast of the latest developments in all areas of this exciting field. Pharmacogenomics is the leading source of commentary and analysis, bringing you the highest quality expert analyses from corporate and academic opinion leaders in the field.