支气管肺发育不良的胎儿起源:宫内炎症的作用。

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Haoting Yu, Danni Li, Xinyi Zhao, Jianhua Fu
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引用次数: 0

摘要

支气管肺发育不良(BPD)是一种常见的婴儿慢性肺部疾病,也是早产最常见的不良后果,尽管早产的主要原因是尽量减少损伤。它被认为是由于肺部在发育过程中受到产前或产后反复损伤所引发的异常修复反应所致。宫内炎症是产前肺损伤的一个重要风险因素,而产前肺损伤与早产儿肺发育不良的关系也日益密切。然而,其具体机制仍不清楚。本综述总结了将宫内炎症与 BPD 联系起来的临床和动物研究。我们评估了宫内炎症如何影响肺泡化和血管发育。此外,我们还讨论了针对宫内炎症的产前治疗策略,以预防或治疗 BPD。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fetal origin of bronchopulmonary dysplasia: contribution of intrauterine inflammation.

Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in infants and the most frequent adverse outcome of premature birth, despite major efforts to minimize injury. It is thought to result from aberrant repair response triggered by either prenatal or recurrent postnatal injury to the lungs during development. Intrauterine inflammation is an important risk factor for prenatal lung injury, which is also increasingly linked to BPD. However, the specific mechanisms remain unclear. This review summarizes clinical and animal research linking intrauterine inflammation to BPD. We assess how intrauterine inflammation affects lung alveolarization and vascular development. In addition, we discuss prenatal therapeutic strategies targeting intrauterine inflammation to prevent or treat BPD.

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来源期刊
Molecular Medicine
Molecular Medicine 医学-生化与分子生物学
CiteScore
8.60
自引率
0.00%
发文量
137
审稿时长
1 months
期刊介绍: Molecular Medicine is an open access journal that focuses on publishing recent findings related to disease pathogenesis at the molecular or physiological level. These insights can potentially contribute to the development of specific tools for disease diagnosis, treatment, or prevention. The journal considers manuscripts that present material pertinent to the genetic, molecular, or cellular underpinnings of critical physiological or disease processes. Submissions to Molecular Medicine are expected to elucidate the broader implications of the research findings for human disease and medicine in a manner that is accessible to a wide audience.
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