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IF 5.5 1区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chinese Journal of Chemistry Pub Date : 2024-09-01 DOI:10.1002/cjoc.202490192

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引用次数: 0

摘要

天然转氨酶Vf-ω-TA的发散蛋白质工程产生了两种有效的突变体，可用于合成利伐斯的明（Rivastigmine）和阿普瑞米拉特（Apremilast）的手性胺前体。在晶体结构和集中诱变的指导下，这些突变体有效地解决了具有高立体阻碍的酮底物的难题。优化的反应参数实现了顺利的转氨作用，具有优异的转化率和完美的立体化学控制（99% ee）。更多详情，请参阅第 2335-2340 页 Zhong 等人的文章。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Divergent protein engineering of the natural transaminase Vf-ω-TA produced two effective mutants for synthesizing chiral amine precursors of Rivastigmine and Apremilast. Guided by crystal structures and focused mutagenesis, these mutants efficiently addressed challenging ketone substrates with high steric hindrance. Optimized reaction parameters achieved smooth transamination with excellent conversions and perfect stereochemical control (> 99% ee). More details are discussed in the article by Zhong et al. on pages 2335—2340.

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来源期刊

Chinese Journal of Chemistry 化学-化学综合

CiteScore

8.80

自引率

14.80%

发文量

422

审稿时长

1.7 months

期刊介绍： The Chinese Journal of Chemistry is an international forum for peer-reviewed original research results in all fields of chemistry. Founded in 1983 under the name Acta Chimica Sinica English Edition and renamed in 1990 as Chinese Journal of Chemistry, the journal publishes a stimulating mixture of Accounts, Full Papers, Notes and Communications in English.