卡介苗免疫诱导的 KLRG1+ NK 细胞对分枝杆菌和艾滋病毒抗原表现出类似记忆的反应

IF 3.7 4区医学 Q2 CELL BIOLOGY

Cellular immunology Pub Date : 2024-09-01 DOI:10.1016/j.cellimm.2024.104865

Manuja Gunasena , Mario Alles , Thorsten Demberg , Will Mulhern , Namal P.M. Liyanage

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引用次数: 0

摘要

卡介苗（Bacille-Calmette-Guérin，BCG）是唯一获批的结核分枝杆菌（MTB）疫苗，不仅能预防结核病（TB），还能预防非相关感染。先天性免疫细胞的 "训练免疫 "被认为是卡介苗提供广泛保护的机制之一。在这里，我们研究了卡介苗对自然杀伤（NK）细胞（一种关键的先天性免疫细胞类型）的影响及其随后对分枝杆菌和 HIV 抗原的反应。我们发现，与 KLRG1- 细胞相比，卡介苗诱导的 KLRG1+ NK 细胞分泌的 IFNγ 明显更高，这表明它们在暴露于这些抗原时会产生类似记忆的反应（p < 0.05）。这些发现对于常规接种卡介苗的艾滋病和结核病高发地区可能很重要。

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BCG immunization induced KLRG1+ NK cells show memory-like responses to mycobacterial and HIV antigens

Bacille-Calmette-Guérin (BCG) is the only approved vaccine against Mycobacterium tuberculosis (MTB), offering protection not only against tuberculosis (TB) but also non-related infections. ‘Trained immunity’ of innate immune cells is considered one of the mechanisms of this broad protection derived through BCG. Here, we investigated the effect of BCG on Natural Killer (NK) cells, a key innate immune cell type, and their subsequent responses to mycobacterial and HIV antigens. We found that BCG-induced KLRG1+ NK cells exhibit significantly higher production of IFNγ, compared to KLRG1− cells, indicating their memory-like responses upon exposure to these antigens (p < 0.05). These findings may be important in regions of high burden of HIV and TB where BCG is routinely administered.

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来源期刊

Cellular immunology 生物-免疫学

CiteScore

8.20

自引率

2.30%

发文量

102

审稿时长

30 days

期刊介绍： Cellular Immunology publishes original investigations concerned with the immunological activities of cells in experimental or clinical situations. The scope of the journal encompasses the broad area of in vitro and in vivo studies of cellular immune responses. Purely clinical descriptive studies are not considered. Research Areas include: • Antigen receptor sites • Autoimmunity • Delayed-type hypersensitivity or cellular immunity • Immunologic deficiency states and their reconstitution • Immunologic surveillance and tumor immunity • Immunomodulation • Immunotherapy • Lymphokines and cytokines • Nonantibody immunity • Parasite immunology • Resistance to intracellular microbial and viral infection • Thymus and lymphocyte immunobiology • Transplantation immunology • Tumor immunity.