植入纳曲酮后意识丧失:病例报告。

Oğuzhan Doğan
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引用次数: 0

摘要

纳曲酮是一种μ阿片受体拮抗剂,用于治疗酒精和阿片类药物使用障碍。纳曲酮不会产生耐受性和依赖性,停药也不会引起戒断症状。由于患者的依从性问题,已开发出纳曲酮的缓释剂型。目前土耳其只有一种皮下注射的缓释剂型。在本病例报告中,我们介绍了纳曲酮缓释植入剂可能产生的严重副作用。一名酗酒的 36 岁男性在植入纳曲酮 1 小时后突然意识模糊,随后 8-10 小时内出现逆行性遗忘。我们未能发现导致精神状态改变的任何医学或神经学原因,但在移除纳曲酮植入物后,症状有所改善。据我们所知,这是首例报告植入纳曲酮后出现意识模糊和逆行性遗忘的病例。关键词纳曲酮植入 副作用 酒精使用障碍 嗜睡 意识模糊
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Loss of Consciousness After Naltrexone Implantation: A Case Report.

Naltrexone is an μ opioid receptor antagonist that is used in alcohol and opiate use disorder. Naltrexone does not constitute tolerance and dependence, and cessation of the drug does not cause withdrawal symptoms. Sustained release form of naltrexone has been developed due to patient compliance issues. There is currently only one sustainedrelease form available in Turkey, which is inserted subcutaneously. In this case report, we present, a probable serious side effect of sustained release naltrexone implant. A 36 years old male with alcohol use disorder, developed a sudden clouding of consciousness one hour after the naltrexone implant application followed by anterograde amnesia in the next 8-10 hours. We were not able to detect any medical or neurological reasons for the altered mental status but after the removal of the naltrexone implant, the symptoms improved. To the best of our knowledge, this is the first case to report clouding of consciousness and anterograde amnesia after naltrexone implantation. Keywords: Naltrexone Implant, Side Effect, Alcohol Use Disorder, Lethargy, Consciousness.

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