Liangjing Lv, Yong Liu, Jiachuan Xiong, Shaobo Wang, Yan Li, Bo Zhang, Yinghui Huang, Jinghong Zhao
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引用次数: 0
摘要
急性肾损伤（AKI）是一种以肾功能急剧下降为特征的临床症状，与肾脏局部炎症和程序性细胞死亡有关。G 蛋白偶联受体（GPCR）是人体内最大的信号转导蛋白家族，市场上约有 40% 的药物以 GPCR 为靶点。在 AKI 模型中，各种 GPCR、前列腺素受体和嘌呤能受体（仅举几例）的表达都发生了显著变化。GPCR 在 AKI 中的作用因其独特的生物功能（如调节血流动力学、代谢重编程和炎症）而备受研究人员关注。因此，在这篇综述中，我们旨在讨论 GPCR 在 AKI 发病机制中的作用，并总结涉及 GPCR 的相关临床试验，以评估 GPCR 及其配体作为 AKI 和 AKI-CKD 过渡期治疗靶点的潜力。
Role of G protein coupled receptors in acute kidney injury.
Acute kidney injury (AKI) is a clinical condition characterized by a rapid decline in kidney function, which is associated with local inflammation and programmed cell death in the kidney. The G protein-coupled receptors (GPCRs) represent the largest family of signaling transduction proteins in the body, and approximately 40% of drugs on the market target GPCRs. The expressions of various GPCRs, prostaglandin receptors and purinergic receptors, to name a few, are significantly altered in AKI models. And the role of GPCRs in AKI is catching the eyes of researchers due to their distinctive biological functions, such as regulation of hemodynamics, metabolic reprogramming, and inflammation. Therefore, in this review, we aim to discuss the role of GPCRs in the pathogenesis of AKI and summarize the relevant clinical trials involving GPCRs to assess the potential of GPCRs and their ligands as therapeutic targets in AKI and the transition to AKI-CKD.
期刊介绍：
Cell Communication and Signaling (CCS) is a peer-reviewed, open-access scientific journal that focuses on cellular signaling pathways in both normal and pathological conditions. It publishes original research, reviews, and commentaries, welcoming studies that utilize molecular, morphological, biochemical, structural, and cell biology approaches. CCS also encourages interdisciplinary work and innovative models, including in silico, in vitro, and in vivo approaches, to facilitate investigations of cell signaling pathways, networks, and behavior.
Starting from January 2019, CCS is proud to announce its affiliation with the International Cell Death Society. The journal now encourages submissions covering all aspects of cell death, including apoptotic and non-apoptotic mechanisms, cell death in model systems, autophagy, clearance of dying cells, and the immunological and pathological consequences of dying cells in the tissue microenvironment.
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