成功利用局部曲美替尼治疗神经纤维瘤病Ⅰ型相关丛状神经纤维瘤。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-03 DOI:10.1111/pde.15710

Leonid Melnikov, Lars Brichta, Nathan J Schloemer

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引用次数: 0

摘要

一名患有神经纤维瘤病 1 型（NF-1）和视神经胶质瘤病史的 11 岁女性出现了进行性乳房皮肤丛状神经纤维瘤。该病变接受了丝裂原活化蛋白激酶抑制剂曲美替尼的局部治疗，结果皮肤丛状神经纤维瘤在两年多的时间里病情稳定，没有进展。该病例表明，局部应用曲美替尼治疗与 NF1 相关的浅表皮肤丛状神经纤维瘤具有潜力，而且不会产生与全身治疗相关的毒性。

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Successful utilization of topical trametinib for neurofibromatosis type I-associated plexiform neurofibroma.

An 11-year-old female with neurofibromatosis type 1 (NF-1) and history of optic glioma presented with a progressive cutaneous plexiform neurofibroma of the breast. The lesion was treated with topical application of a mitogen-activated protein kinase inhibitor, trametinib, resulting in stable, non-progression cutaneous plexiform neurofibroma for greater than 2 years. This case demonstrates the potential application of topical trametinib for NF1-associated superficial cutaneous plexiform neurofibroma without the toxicities associated with systemic treatment.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.