基于各种理化参数的欧洲 37 种泪液替代品概览。

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2024-10-01 Epub Date: 2024-09-03 DOI:10.1007/s40123-024-01023-9

Adrien Paschier, Aurélie Manuelli, Laure Chauchat, Morgane Legall, Hayette Rebika, Marwan Sahyoun, Camille Guerin

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引用次数: 0

摘要

简介干眼症（DED）是全球最常见的眼部疾病之一，人工泪液是主要的治疗方法。尽管人工泪液在欧洲市场上广泛供应，但缺乏基于其物理化学特性的既定分类。因此，我们的研究目的是：(i) 开发一种分析方法，测量商业化产品中透明质酸（HA）的浓度和分子量（MW）；(ii) 根据其各种理化参数提出一个概述：方法：测量或确定透明质酸的固有粘度和分子量，以及渗透压、pH 值、流变曲线和粘度。开发了一种特定方法，使用液体尺寸排阻色谱系统测量平均固有粘度和 HA 含量。使用 Mark-Houwink 公式确定了 MW：结果：分析了欧洲 37 种商业化产品，其中 21 种含有 HA。Thealose®、Thealoz Duo® Gel 和 Hyabak® 的 HA 最大分子量最低（300 kDa），Vismed® Multi、Vismed® Gel 和 Neovis® Gel 的 HA 最大分子量最高（1300 kDa）。Treovis® 和 Systane® Ultra 的 pH 值分别为 5.94 和 8.06。Neovis® 和 Treovis® 的渗透压分别在 148 mOsm/L 和 325 mOsm/L 之间。粘度变化很大，从 Hylolipid® 的 0.38 mPas-s 到 Thealoz® Duo Gel 的 337.47 mPas-s。最后，流变曲线分析显示了不同的剪切稀化行为：结论：虽然完美的滴眼液并不存在，但有多种选择可供选择。这项研究根据几种物理化学特性加深了我们对欧洲市场上主要泪液替代品的了解。更好地了解和认识这些参数对于为 DED 患者提供最佳治疗至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Overview of 37 Tear Substitutes in Europe Based on Various Physicochemical Parameters.

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Overview of 37 Tear Substitutes in Europe Based on Various Physicochemical Parameters.

Introduction: Dry eye disease (DED) is one of the most prevalent eye conditions worldwide, with artificial tears serving as a primary treatment option. Despite their wide availability on the European market, there is a lack of established classifications based on their physicochemical properties. The aim of our study was therefore (i) to develop an analytical method that measures the concentration and the molecular weight (MW) of the hyaluronic acid (HA) in commercialized products, and (ii) to propose an overview based on their various physicochemical parameters.

Methods: The intrinsic viscosity and MW of the HA, as well as osmolarity, pH, rheological profile, and viscosity, were measured or determined. A specific method was developed to measure the average intrinsic viscosity and HA content using a liquid size-exclusion chromatography system. The MW was determined using the Mark-Houwink equation.

Results: Thirty-seven products commercialized in Europe were analyzed, with 21 of them containing HA. The HA MW was lowest (300 kDa) for Thealose^®, Thealoz Duo^® Gel, and Hyabak^®, and highest (1300 kDa) for Vismed^® Multi, Vismed^® Gel, and Neovis^® Gel. The pH values varied between 5.94 for Treovis^® and 8.06 for Systane^® Ultra. Osmolarity ranged between 148 mOsm/L and 325 mOsm/L for Neovis^® and Treovis^®, respectively. Viscosity was highly variable, ranging from 0.38 mPas·s for Hylolipid^® to 337.47 mPas·s for Thealoz^® Duo Gel. Finally, rheological profile analysis revealed different shear-thinning behaviors.

Conclusion: While the perfect eye drop does not exist, a multitude of options are available to choose from. This study improves our understanding of the major tear substitutes available on the European market based on several physicochemical properties. A better understanding and awareness of these parameters is crucial in order to offer the best treatment for patients with DED.

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. 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