癌症治疗相关的唾液功能障碍。

IF 13.3 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Cristina Paz, Annemarie Glassey, Abigail Frick, Sarah Sattar, Nicholas G Zaorsky, Grace C Blitzer, Randall J Kimple
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引用次数: 0

摘要

唾液腺功能障碍是癌症治疗的常见副作用。唾液功能在重要的日常活动中起着关键作用。因此,唾液功能的变化会严重影响癌症患者的生活质量。我们将讨论唾液腺解剖学和生理学,以了解化疗、骨髓移植、免疫疗法和放疗等抗癌疗法是如何损害唾液功能的。我们讨论了临床上量化口腔干燥症的方法,包括经过验证的生活质量工具和直接测量唾液功能的方法的优势和局限性。以辐射引起的唾液功能障碍为模型,介绍了治疗癌症治疗引起的口干的现有和新兴方法。介绍了目前唾液促凝剂和唾液类似物的局限性。介绍了新出现的方法,包括细胞和基因疗法以及新型药物疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cancer therapy-related salivary dysfunction.

Salivary gland dysfunction is a common side effect of cancer treatments. Salivary function plays key roles in critical daily activities. Consequently, changes in salivary function can profoundly impair quality of life for cancer patients. We discuss salivary gland anatomy and physiology to understand how anticancer therapies such as chemotherapy, bone marrow transplantation, immunotherapy, and radiation therapy impair salivary function. We discuss approaches to quantify xerostomia in the clinic, including the advantages and limitations of validated quality-of-life instruments and approaches to directly measuring salivary function. Current and emerging approaches to treat cancer therapy-induced dry mouth are presented using radiation-induced salivary dysfunction as a model. Limitations of current sialagogues and salivary analogues are presented. Emerging approaches, including cellular and gene therapy and novel pharmacologic approaches, are described.

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来源期刊
Journal of Clinical Investigation
Journal of Clinical Investigation 医学-医学:研究与实验
CiteScore
24.50
自引率
1.30%
发文量
1034
审稿时长
2 months
期刊介绍: The Journal of Clinical Investigation, established in 1924 by the ASCI, is a prestigious publication that focuses on breakthroughs in basic and clinical biomedical science, with the goal of advancing the field of medicine. With an impressive Impact Factor of 15.9 in 2022, it is recognized as one of the leading journals in the "Medicine, Research & Experimental" category of the Web of Science. The journal attracts a diverse readership from various medical disciplines and sectors. It publishes a wide range of research articles encompassing all biomedical specialties, including Autoimmunity, Gastroenterology, Immunology, Metabolism, Nephrology, Neuroscience, Oncology, Pulmonology, Vascular Biology, and many others. The Editorial Board consists of esteemed academic editors who possess extensive expertise in their respective fields. They are actively involved in research, ensuring the journal's high standards of publication and scientific rigor.
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